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Sypl2 Gene Detail
Summary
  • Symbol
    Sypl2
  • Name
    synaptophysin like 2
  • Synonyms
    Mg29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1328311
    NCBI Gene: 17306
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108119582-108133915 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.87 cM, cytoband F3-H2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    290 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328311
 protein coding gene Chr3:108118788-108133964 (-)
129S1/SvImJ ENSMUSG00200035002
 protein coding gene Chr3:104734764-104749936 (-)
A/J ENSMUSG00195024988
 protein coding gene Chr3:105161216-105176388 (-)
AKR/J ENSMUSG00220030261
 protein coding gene Chr3:103524845-103540017 (-)
BALB/cJ ENSMUSG00180015684
 protein coding gene Chr3:105106562-105121734 (-)
C3H/HeJ ENSMUSG00175029020
 protein coding gene Chr3:104641316-104656488 (-)
C57BL/6NJ ENSMUSG00215023530
 protein coding gene Chr3:105369189-105384365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025525
 protein coding gene Chr3:102423348-102439260 (-)
CAST/EiJ ENSTCUG00005026368
 protein coding gene Chr3:105647855-105663138 (-)
CBA/J ENSMUSG00210007410
 protein coding gene Chr3:105263176-105278352 (-)
DBA/2J ENSMUSG00185019756
 protein coding gene Chr3:105732516-105747688 (-)
FVB/NJ ENSMUSG00205022859
 protein coding gene Chr3:104299187-104314359 (-)
JF1/MsJ ENSUMUG00000003982
 protein coding gene Chr3:104707978-104723304 (-)
LP/J ENSMUSG00230014604
 protein coding gene Chr3:107647763-107662931 (-)
NOD/ShiLtJ ENSMUSG00190026609
 protein coding gene Chr3:105970608-105985780 (-)
NZO/HlLtJ ENSMUSG00225018413
 protein coding gene Chr3:110153683-110168957 (-)
PWK/PhJ ENSLUMG00010023680
 protein coding gene Chr3:104571341-104586633 (-)
SPRET/EiJ ENSMSPG00010033166
 protein coding gene Chr3:105071751-105087514 (-)
WSB/EiJ ENSIUOG00005004072
 protein coding gene Chr3:105285076-105300244 (-)



Homology
more
  • Human Ortholog
    SYPL2, synaptophysin like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYPL2, synaptophysin like 2
  • Synonyms
    MG29
  • Links
    NCBI Gene ID: 284612
    UniProt: Q5VXT5

  • Chr Location
    1p13.3; chr1:109466542-109482134 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are viable and fertile, but exhibit reduced body weight, abnormal skeletal muscle membranes and irregular skeletal muscle contractility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    601
  • Tissues
    3
  • cDNA Data
    22
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17306 NCBI Gene Model | MGI Sequence Detail 14334 C57BL/6J ±  kb
    transcript NM_008596 RefSeq | MGI Sequence Detail 3247 C57BL/6  
    polypeptide O89104 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 23
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139755
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:48931 Shimuta M, et al., Structure and expression of mitsugumin29 gene. FEBS Lett. 1998 Jul 17;431(2):263-7
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory