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Morc1 Gene Detail
Summary
  • Symbol
    Morc1
  • Name
    microrchidia 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316740
    NCBI Gene: 17450
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:48251600-48451263 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 30.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7560 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316740
 protein coding gene Chr16:48251600-48451268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022865
 protein coding gene Chr16:47308686-47512545 (+)
A/J MGP_AJ_G0022830
 protein coding gene Chr16:45212217-45406962 (+)
AKR/J MGP_AKRJ_G0022803
 protein coding gene Chr16:46712226-46926051 (+)
BALB/cJ MGP_BALBcJ_G0022832
 protein coding gene Chr16:45269127-45458680 (+)
C3H/HeJ MGP_C3HHeJ_G0022595
 protein coding gene Chr16:46810478-47019968 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023279
 protein coding gene Chr16:48473897-48677453 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020792
 protein coding gene Chr16:45360173-45548760 (+)
CAST/EiJ MGP_CASTEiJ_G0022121
 protein coding gene Chr16:47068465-47261515 (+)
CBA/J MGP_CBAJ_G0022568
 protein coding gene Chr16:50389848-50602279 (+)
DBA/2J MGP_DBA2J_G0022699
 protein coding gene Chr16:44932465-45125431 (+)
FVB/NJ MGP_FVBNJ_G0022675
 protein coding gene Chr16:44814235-45014151 (+)
LP/J MGP_LPJ_G0022767
 protein coding gene Chr16:47045957-47247977 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022693
 protein coding gene Chr16:50065938-50281138 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023294
 protein coding gene Chr16:46708084-46913216 (+)
PWK/PhJ MGP_PWKPhJ_G0021861
 protein coding gene Chr16:45288458-45483643 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021691
 protein coding gene Chr16:46624917-46811620 (+)
WSB/EiJ MGP_WSBEiJ_G0022166
 protein coding gene Chr16:46770161-46966360 (+)



Homology
more
  • Human Ortholog
    MORC1, MORC family CW-type zinc finger 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MORC1, MORC family CW-type zinc finger 1
  • Synonyms
    CT33, MORC, ZCW6
  • Links
    NCBI Gene ID: 27136
    neXtProt AC: NX_Q86VD1
    UniProt: Q86VD1

  • Chr Location
    3q13.13; chr3:108958248-109118134 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Morc1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this locus results in small testes and male sterility, the latter owing to meiotic arrest. Mutant females exhibited histologically normal ovaries and were fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022652 Ensembl Gene Model | MGI Sequence Detail 199664 C57BL/6J ±  kb
    transcript ENSMUST00000023330 Ensembl | MGI Sequence Detail 3045 Not Applicable  
    polypeptide ENSMUSP00000023330 Ensembl | MGI Sequence Detail 950 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 16

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:51211 Watson ML, et al., Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14361-6
    • Latest
      J:360874 Uneme Y, et al., Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2317095121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory