Morc1 MGI Mouse Gene Detail - MGI:1316740

Symbol

Morc1
Name

microrchidia 1

Feature Type

protein coding gene
IDs

MGI:1316740
NCBI Gene: 17450
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr16:48251600-48451263 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 30.75 cM
Mapping Data

2 experiments

SNPs within 2kb

7560 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1316740	protein coding gene	Chr16:48251600-48451268 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022865	protein coding gene	Chr16:47308686-47512545 (+)
A/J	MGP_AJ_G0022830	protein coding gene	Chr16:45212217-45406962 (+)
AKR/J	MGP_AKRJ_G0022803	protein coding gene	Chr16:46712226-46926051 (+)
BALB/cJ	MGP_BALBcJ_G0022832	protein coding gene	Chr16:45269127-45458680 (+)
C3H/HeJ	MGP_C3HHeJ_G0022595	protein coding gene	Chr16:46810478-47019968 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023279	protein coding gene	Chr16:48473897-48677453 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020792	protein coding gene	Chr16:45360173-45548760 (+)
CAST/EiJ	MGP_CASTEiJ_G0022121	protein coding gene	Chr16:47068465-47261515 (+)
CBA/J	MGP_CBAJ_G0022568	protein coding gene	Chr16:50389848-50602279 (+)
DBA/2J	MGP_DBA2J_G0022699	protein coding gene	Chr16:44932465-45125431 (+)
FVB/NJ	MGP_FVBNJ_G0022675	protein coding gene	Chr16:44814235-45014151 (+)
LP/J	MGP_LPJ_G0022767	protein coding gene	Chr16:47045957-47247977 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022693	protein coding gene	Chr16:50065938-50281138 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023294	protein coding gene	Chr16:46708084-46913216 (+)
PWK/PhJ	MGP_PWKPhJ_G0021861	protein coding gene	Chr16:45288458-45483643 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021691	protein coding gene	Chr16:46624917-46811620 (+)
WSB/EiJ	MGP_WSBEiJ_G0022166	protein coding gene	Chr16:46770161-46966360 (+)

Human Ortholog

MORC1, MORC family CW-type zinc finger 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MORC1, MORC family CW-type zinc finger 1
Synonyms

CT33, MORC, ZCW6
Links

HGNC:7198

NCBI Gene ID: 27136

UniProt: Q86VD1
Chr Location

3q13.13; chr3:108958248-109118134 (-) GRCh38

MGI Vertebrate Homology

Morc1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MORC1
Gene Tree

Morc1

Diseases

1 with Morc1 mouse models

Human Disease

Mouse Models

melancholic depression

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

121
Endonuclease-mediated

2
Gene trapped

115
Targeted

3
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

82 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this locus results in small testes and male sterility, the latter owing to meiotic arrest. Mutant females exhibited histologically normal ovaries and were fertile.

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All GO Annotations

11
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

9
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase morc1

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS37351.1

Ensembl

ENSMUSG00000022652 (Evidence)
NCBI Gene

17450

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022652	Ensembl Gene Model \| MGI Sequence Detail	199664	C57BL/6J	± kb
transcript	ENSMUST00000023330	Ensembl \| MGI Sequence Detail	3045	Not Applicable
polypeptide	ENSMUSP00000023330	Ensembl \| MGI Sequence Detail	950	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010522 MORC family CW-type zinc finger protein 1

(term hierarchy)
InterPro Domains

IPR036890 Histidine kinase/HSP90-like ATPase superfamily

IPR041006 Morc, S5 domain 2-like

IPR011124 Zinc finger, CW-type

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All nucleic 19

Genomic 3

cDNA 16

Microarray probesets 3

Summaries

All 37

Developmental Gene Expression 5

Diseases 1

Gene Ontology 5

Phenotypes 14
Earliest

J:51211 Watson ML, et al., Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14361-6
Latest

J:360874 Uneme Y, et al., Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes. Proc Natl Acad Sci U S A. 2024 Mar 26;121(13):e2317095121

TSS for Morc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138654	Chr16:48251644-48251686 (+)	65 bp
Tssr138655	Chr16:48251693-48251702 (+)	98 bp
Tssr138656	Chr16:48299923-48299940 (+)	48,332 bp
Tssr138657	Chr16:48414968-48414983 (+)	163,376 bp
Tssr138658	Chr16:48414990-48415043 (+)	163,417 bp
Tssr138659	Chr16:48419246-48419249 (+)	167,648 bp
Tssr138660	Chr16:48432019-48432034 (+)	180,427 bp
Tssr138661	Chr16:48432048-48432083 (+)	180,466 bp
Tssr138662	Chr16:48432088-48432104 (+)	180,496 bp
Tssr138663	Chr16:48432145-48432148 (+)	180,547 bp
Tssr138664	Chr16:48432151-48432171 (+)	180,561 bp
Tssr138665	Chr16:48432172-48432183 (+)	180,578 bp
Tssr138666	Chr16:48432207-48432216 (+)	180,612 bp
Tssr138667	Chr16:48432523-48432569 (+)	180,946 bp
Tssr138668	Chr16:48450281-48450285 (+)	198,683 bp
Tssr138669	Chr16:48450351-48450374 (+)	198,763 bp
Tssr138670	Chr16:48450517-48450529 (+)	198,923 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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