Hk2 MGI Mouse Gene Detail - MGI:1315197

Symbol

Hk2
Name

hexokinase 2
Synonyms

HKII

Feature Type

protein coding gene
IDs

MGI:1315197
NCBI Gene: 15277
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr6:82702006-82751435 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 35.94 cM
Mapping Data

4 experiments

SNPs within 2kb

403 from dbSNP Build 142
Strain Annotations

13
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1315197	protein coding gene	Chr6:82702004-82751437 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030906	protein coding gene	Chr6:83704653-83757454 (-)
A/J	MGP_AJ_G0030875	protein coding gene	Chr6:80510473-80559689 (-)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0030885	protein coding gene	Chr6:80524241-80573688 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0031345	protein coding gene	Chr6:85971729-86023093 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028531	protein coding gene	Chr6:78864989-78913663 (-)
CAST/EiJ	MGP_CASTEiJ_G0029994	protein coding gene	Chr6:82804308-82866630 (-)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0030725	protein coding gene	Chr6:79832084-79880521 (-)
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0030714	protein coding gene	Chr6:93694877-93750290 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031369	protein coding gene	Chr6:82635159-82687974 (-)
PWK/PhJ	MGP_PWKPhJ_G0029709	protein coding gene	Chr6:78717430-78767607 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029537	protein coding gene	Chr6:81499194-81548462 (-)
WSB/EiJ	MGP_WSBEiJ_G0030075	protein coding gene	Chr6:83078910-83128057 (-)

Human Ortholog

HK2, hexokinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HK2, hexokinase 2
Synonyms

HKII, HXK2
Links

HGNC:4923

NCBI Gene ID: 3099

neXtProt AC: NX_P52789

UniProt: P52789
Chr Location

2p12; chr2:74834127-74893359 (+) GRCh38

MGI Vertebrate Homology

Hk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HK2
Gene Tree

Hk2

Diseases

2 with human HK2 associations

				Human Disease	Mouse Models
				obesity IDs obesity DOID:9970 EFO:0001073 ICD10CM:E66.9 ICD9CM:278.00 MESH:D009765 NCI:C159658 OMIM:601665 UMLS_CUI:C0028754
				type 2 diabetes mellitus IDs type 2 diabetes mellitus DOID:9352 ICD10CM:E11 KEGG:04930 MESH:D003924 NCI:C26747 OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036 UMLS_CUI:C0011860

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
6 phenotypes from multigenic genotypes
1 images
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

54
Endonuclease-mediated

3
Gene trapped

44
Spontaneous

1
Targeted

5
Transgenic

1
Genomic Mutations

2 involving Hk2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.

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All GO Annotations

56
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

911
Tissues

133
cDNA Data

10
Literature Summary

34

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HK2

Xenbase hk2

ZFIN hk2

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All Sequences

46
RefSeq

6
UniProt

3
CCDS

CCDS20263.1

Ensembl

ENSMUSG00000000628 (Evidence)
NCBI Gene

15277

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000628	Ensembl Gene Model \| MGI Sequence Detail	49430	C57BL/6J	± kb
transcript	ENSMUST00000000642	Ensembl \| MGI Sequence Detail	5513	Not Applicable
polypeptide	ENSMUSP00000000642	Ensembl \| MGI Sequence Detail	917	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008609 hexokinase-2

(term hierarchy)
EC

2.7.1.1
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR001312 Hexokinase

IPR019807 Hexokinase, binding site

IPR022673 Hexokinase, C-terminal

IPR022672 Hexokinase, N-terminal

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All nucleic 24

Genomic 5

cDNA 11

Primer pair 8

Microarray probesets 4

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MGI:2141455

Summaries

All 127

Developmental Gene Expression 34

Diseases 1

Gene Ontology 14

Phenotypes 39
Earliest

J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
Latest

J:341079 Zhang L, et al., STING is a cell-intrinsic metabolic checkpoint restricting aerobic glycolysis by targeting HK2. Nat Cell Biol. 2023 Aug;25(8):1208-1222

TSS for Hk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61595	Chr6:82751429-82751444 (-)	-2 bp
Tssr61594	Chr6:82751408-82751425 (-)	18 bp
Tssr61593	Chr6:82737803-82737826 (-)	13,620 bp
Tssr61592	Chr6:82737120-82737163 (-)	14,293 bp
Tssr61591	Chr6:82731014-82731035 (-)	20,410 bp
Tssr61590	Chr6:82729716-82729720 (-)	21,717 bp
Tssr61589	Chr6:82728847-82728861 (-)	22,581 bp
Tssr61588	Chr6:82714261-82714285 (-)	37,162 bp
Tssr61587	Chr6:82707820-82707832 (-)	43,609 bp
Tssr61586	Chr6:82703629-82703638 (-)	47,801 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23