Lrrc23 MGI Mouse Gene Detail - MGI:1315192 - leucine rich repeat containing 23

Symbol

Lrrc23
Name

leucine rich repeat containing 23
Synonyms

4921537K05Rik, Lrpb7

Feature Type

protein coding gene
IDs

MGI:1315192
NCBI Gene: 16977
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr6:124746826-124756690 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 59.17 cM
Mapping Data

2 experiments

SNPs within 2kb

293 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1315192	protein coding gene	Chr6:124746826-124757411 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031267	protein coding gene	Chr6:128074009-128082960 (-)
A/J	MGP_AJ_G0031237	protein coding gene	Chr6:123260905-123270580 (-)
AKR/J	MGP_AKRJ_G0031165	protein coding gene	Chr6:126619481-126629009 (-)
BALB/cJ	MGP_BALBcJ_G0031245	protein coding gene	Chr6:122860382-122870017 (-)
C3H/HeJ	MGP_C3HHeJ_G0030968	protein coding gene	Chr6:126670596-126680938 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031701	protein coding gene	Chr6:131463560-131473082 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028851	protein coding gene	Chr6:120447819-120475591 (-)
CAST/EiJ	MGP_CASTEiJ_G0030349	protein coding gene	Chr6:126873913-126883355 (-)
CBA/J	MGP_CBAJ_G0030929	protein coding gene	Chr6:136493685-136503412 (-)
DBA/2J	MGP_DBA2J_G0031085	protein coding gene	Chr6:122186048-122195807 (-)
FVB/NJ	MGP_FVBNJ_G0031035	protein coding gene	Chr6:121089953-121100047 (-)
LP/J	MGP_LPJ_G0031165	protein coding gene	Chr6:128250275-128260559 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031073	protein coding gene	Chr6:140547192-140560093 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031736	protein coding gene	Chr6:126510744-126523053 (-)
PWK/PhJ	MGP_PWKPhJ_G0030064	protein coding gene	Chr6:120415216-120425612 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029893	protein coding gene	Chr6:124589104-124597338 (-)
WSB/EiJ	MGP_WSBEiJ_G0030434	protein coding gene	Chr6:126873300-126883577 (-)

Human Ortholog

LRRC23, leucine rich repeat containing 23

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC23, leucine rich repeat containing 23
Synonyms

LRPB7, SPGF92
Links

HGNC:19138

NCBI Gene ID: 10233

neXtProt AC: NX_Q53EV4

UniProt: Q53EV4
Chr Location

12p13.31; chr12:6873569-6914241 (+) GRCh38

MGI Vertebrate Homology

Lrrc23 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRC23
Gene Tree

Lrrc23

Diseases

1 with human LRRC23 associations

				Human Disease	Mouse Models
				spermatogenic failure 92 IDs spermatogenic failure 92 DOID:0070591 OMIM:620848

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

6
Gene trapped

9
Targeted

3
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males are infertile due to radial spoke disorganization and impaired spermatozoa motility.

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All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

9
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc23

ZFIN lrrc23

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All Sequences

53
RefSeq

14
UniProt

3
CCDS

CCDS20528.1

Ensembl

ENSMUSG00000030125 (Evidence)
NCBI Gene

16977

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030125	Ensembl Gene Model \| MGI Sequence Detail	9865	C57BL/6J	± kb
transcript	ENSMUST00000032218	Ensembl \| MGI Sequence Detail	1470	Not Applicable
polypeptide	ENSMUSP00000032218	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032055 leucine-rich repeat-containing protein 23

(term hierarchy)
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050836 SDS22/Internalin LRR-containing

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All nucleic 13

Genomic 1

cDNA 11

Primer pair 1

Microarray probesets 4

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MGI:1918196

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lrrc23:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr63165	Chr6:124757405-124757437 (-)	-731 bp
Tssr63164	Chr6:124756709-124756726 (-)	-28 bp
Tssr63163	Chr6:124756649-124756705 (-)	13 bp
Tssr2010	Chr6:124756629-124756643 (-)	54 bp
Tssr63162	Chr6:124756600-124756611 (-)	84 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24