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Lrrc23 Gene Detail
Summary
  • Symbol
    Lrrc23
  • Name
    leucine rich repeat containing 23
  • Synonyms
    4921537K05Rik, Lrpb7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315192
    NCBI Gene: 16977
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124746826-124756690 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    293 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315192
 protein coding gene Chr6:124746826-124757411 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031267
 protein coding gene Chr6:128074009-128082960 (-)
A/J MGP_AJ_G0031237
 protein coding gene Chr6:123260905-123270580 (-)
AKR/J MGP_AKRJ_G0031165
 protein coding gene Chr6:126619481-126629009 (-)
BALB/cJ MGP_BALBcJ_G0031245
 protein coding gene Chr6:122860382-122870017 (-)
C3H/HeJ MGP_C3HHeJ_G0030968
 protein coding gene Chr6:126670596-126680938 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031701
 protein coding gene Chr6:131463560-131473082 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028851
 protein coding gene Chr6:120447819-120475591 (-)
CAST/EiJ MGP_CASTEiJ_G0030349
 protein coding gene Chr6:126873913-126883355 (-)
CBA/J MGP_CBAJ_G0030929
 protein coding gene Chr6:136493685-136503412 (-)
DBA/2J MGP_DBA2J_G0031085
 protein coding gene Chr6:122186048-122195807 (-)
FVB/NJ MGP_FVBNJ_G0031035
 protein coding gene Chr6:121089953-121100047 (-)
LP/J MGP_LPJ_G0031165
 protein coding gene Chr6:128250275-128260559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031073
 protein coding gene Chr6:140547192-140560093 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031736
 protein coding gene Chr6:126510744-126523053 (-)
PWK/PhJ MGP_PWKPhJ_G0030064
 protein coding gene Chr6:120415216-120425612 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029893
 protein coding gene Chr6:124589104-124597338 (-)
WSB/EiJ MGP_WSBEiJ_G0030434
 protein coding gene Chr6:126873300-126883577 (-)



Homology
more
  • Human Ortholog
    LRRC23, leucine rich repeat containing 23
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRC23, leucine rich repeat containing 23
  • Synonyms
    LRPB7, SPGF92
  • Links
    NCBI Gene ID: 10233
    UniProt: Q53EV4

  • Chr Location
    12p13.31; chr12:6873569-6914241 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LRRC23 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile due to radial spoke disorganization and impaired spermatozoa motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    9
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030125 Ensembl Gene Model | MGI Sequence Detail 9865 C57BL/6J ±  kb
    transcript ENSMUST00000032218 Ensembl | MGI Sequence Detail 1470 Not Applicable  
    polypeptide ENSMUSP00000032218 Ensembl | MGI Sequence Detail 340 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918196
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory