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Chaf1b Gene Detail
Summary
  • Symbol
    Chaf1b
  • Name
    chromatin assembly factor 1, subunit B
  • Synonyms
    2600017H24Rik, CAF1, CAF1A, CAF1P60, CAF-1 subunit B, CAF-I 60 kDa subunit, CAF-IP60, MPHOSPH7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314881
    NCBI Gene: 110749
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:93680801-93703003 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 54.96 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    745 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314881
 protein coding gene Chr16:93680789-93703003 (+)
129S1/SvImJ ENSMUSG00200037089
 protein coding gene Chr16:90615330-90637485 (+)
A/J ENSMUSG00195028253
 protein coding gene Chr16:90373051-90395206 (+)
AKR/J ENSMUSG00220015694
 protein coding gene Chr16:90618366-90640521 (+)
BALB/cJ ENSMUSG00180013955
 protein coding gene Chr16:90447034-90469189 (+)
C3H/HeJ ENSMUSG00175015132
 protein coding gene Chr16:90784173-90806328 (+)
C57BL/6NJ ENSMUSG00215016756
 protein coding gene Chr16:90571276-90593375 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020984
 protein coding gene Chr16:88478410-88501183 (+)
CAST/EiJ ENSTCUG00005018550
 protein coding gene Chr16:90173294-90195679 (+)
CBA/J ENSMUSG00210035235
 protein coding gene Chr16:90691703-90713858 (+)
DBA/2J ENSMUSG00185033024
 protein coding gene Chr16:90631126-90653281 (+)
FVB/NJ ENSMUSG00205021562
 protein coding gene Chr16:90410625-90432780 (+)
JF1/MsJ ENSUMUG00000015159
 protein coding gene Chr16:90778962-90801360 (+)
LP/J ENSMUSG00230024739
 protein coding gene Chr16:93161934-93184089 (+)
NOD/ShiLtJ ENSMUSG00190024807
 protein coding gene Chr16:90599617-90621772 (+)
NZO/HlLtJ ENSMUSG00225030117
 protein coding gene Chr16:96277454-96299609 (+)
PWK/PhJ ENSLUMG00010013426
 protein coding gene Chr16:90415828-90437999 (+)
SPRET/EiJ ENSMSPG00010019657
 protein coding gene Chr16:91526581-91547695 (+)
WSB/EiJ ENSIUOG00005018079
 protein coding gene Chr16:90520579-90542692 (+)



Homology
more
  • Human Ortholog
    CHAF1B, chromatin assembly factor 1 subunit B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHAF1B, chromatin assembly factor 1 subunit B
  • Synonyms
    CAF-1, CAF1, CAF1A, CAF1P60, CAF-IP60, MPHOSPH7, MPP7
  • Links
    NCBI Gene ID: 8208
    UniProt: Q13112

  • Chr Location
    21q22.12-q22.13; chr21:36385354-36419015 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in hematopoietic cells exhibit premature death, pancytopenia, reduced bone amrrow and hematopoietic stem cells, and reduced hematopoietic reconstitution.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    160
  • cDNA Data
    10
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110749 NCBI Gene Model | MGI Sequence Detail 22203 C57BL/6J ±  kb
    transcript NM_001419178 RefSeq | MGI Sequence Detail 2300 ZRU/MplStud  
    polypeptide Q9D0N7 UniProt | EBI | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000005403 chromatin assembly factor 1 subunit B
      (term hierarchy)
    • InterPro Domains
      IPR055410 CAF1B/HIR1, beta-propeller domain
      IPR029129 Chromatin assembly factor 1 subunit B, C-terminal
      IPR045145 Chromatin assembly factor 1 subunit Cac2/CHAF1B/FAS2
      IPR001632 G-protein beta subunit-like, WD40 repeats
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q9D0N7 4 sites, 1 N-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 11
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1919322, MGI:2146692
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 6
      Diseases 6
      Gene Ontology 7
      Phenotypes 104
    • Earliest
      J:38619 Wilming LG, et al., The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients. Hum Mol Genet. 1997 Feb;6(2):247-58
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory