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Nthl1 Gene Detail
Summary
  • Symbol
    Nthl1
  • Name
    nth (endonuclease III)-like 1 (E.coli)
  • Synonyms
    Nth1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313275
    NCBI Gene: 18207
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24851654-24857811 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.42 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313275
protein coding gene Chr17:24851654-24857812 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023309
protein coding gene Chr17:23628162-23634302 (+)
A/J MGP_AJ_G0023269
protein coding gene Chr17:22990500-22996640 (+)
AKR/J MGP_AKRJ_G0023236
protein coding gene Chr17:23071975-23078119 (+)
BALB/cJ MGP_BALBcJ_G0023274
protein coding gene Chr17:23177341-23183482 (+)
C3H/HeJ MGP_C3HHeJ_G0023034
protein coding gene Chr17:23430566-23436707 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023718
protein coding gene Chr17:24681207-24687363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021193
protein coding gene Chr17:20463399-20469527 (+)
CAST/EiJ MGP_CASTEiJ_G0022536
protein coding gene Chr17:23280122-23286259 (+)
CBA/J MGP_CBAJ_G0023010
protein coding gene Chr17:25525477-25531618 (+)
DBA/2J MGP_DBA2J_G0023139
protein coding gene Chr17:22580677-22586817 (+)
FVB/NJ MGP_FVBNJ_G0023109
protein coding gene Chr17:22304427-22310567 (+)
LP/J MGP_LPJ_G0023216
protein coding gene Chr17:23943604-23949744 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023128
protein coding gene Chr17:25232045-25238185 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023755
protein coding gene Chr17:23347201-23353341 (+)
PWK/PhJ MGP_PWKPhJ_G0022285
protein coding gene Chr17:21328190-21334329 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022103
protein coding gene Chr17:21389737-21395871 (+)
WSB/EiJ MGP_WSBEiJ_G0022599
protein coding gene Chr17:23417328-23423463 (+)



Homology
more
  • Human Ortholog
    NTHL1, nth like DNA glycosylase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTHL1, nth like DNA glycosylase 1
  • Synonyms
    FAP3, hNTH1, NTH1, OCTS3
  • Links
    NCBI Gene ID: 4913
    neXtProt AC: NX_P78549
    UniProt: P78549

  • Chr Location
    16p13.3; chr16:2039815-2047872 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NTHL1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit slower hepatic repair of thymine glycol DNA lesions after treatment with X-rays. Mutants are overtly normal, long-lived, and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041429 Ensembl Gene Model | MGI Sequence Detail 6158 C57BL/6J ±  kb
    transcript ENSMUST00000047611 Ensembl | MGI Sequence Detail 1079 Not Applicable  
    polypeptide ENSMUSP00000047413 Ensembl | MGI Sequence Detail 300 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 15

      Microarray probesets 3
    References
    more
    • Summaries
      All 43
      Gene Ontology 9
      Phenotypes 15
    • Earliest
      J:50110 Sarker AH, et al., Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III. J Mol Biol. 1998 Oct 2;282(4):761-74
    • Latest
      J:290299 Chimienti G, et al., Deletion of OGG1 Results in a Differential Signature of Oxidized Purine Base Damage in mtDNA Regions. Int J Mol Sci. 2019 Jul 5;20(13):3302

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    01/17/2023
    MGI 6.22
    The Jackson Laboratory