Tpst2 MGI Mouse Gene Detail - MGI:1309516 - protein-tyrosine sulfotransferase 2

Symbol

Tpst2
Name

protein-tyrosine sulfotransferase 2
Synonyms

D5Ucla3, grm, grt, Tango13b

Feature Type

protein coding gene
IDs

MGI:1309516
NCBI Gene: 22022
Alliance

genome feature page
Transcription Start Sites

12 TSS

Sequence Map

Chr5:112424557-112463227 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 54.65 cM
Mapping Data

11 experiments

SNPs within 2kb

1065 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1309516	protein coding gene	Chr5:112424548-112463227 (+)
129S1/SvImJ	ENSMUSG00200023151	protein coding gene	Chr5:106193098-106202438 (+)
A/J	ENSMUSG00195035480	protein coding gene	Chr5:105701783-105711171 (+)
AKR/J	ENSMUSG00220050713	protein coding gene	Chr5:105212435-105221777 (+)
BALB/cJ	ENSMUSG00180040174	protein coding gene	Chr5:105843354-105852747 (+)
C3H/HeJ	ENSMUSG00175043228	protein coding gene	Chr5:107824992-107834356 (+)
C57BL/6NJ	ENSMUSG00215028389	protein coding gene	Chr5:105850189-105859586 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027561	protein coding gene	Chr5:105203072-105241427 (+)
CAST/EiJ	ENSTCUG00005020900	protein coding gene	Chr5:105026603-105036006 (+)
CBA/J	ENSMUSG00210033160	protein coding gene	Chr5:106577068-106586432 (+)
DBA/2J	ENSMUSG00185042621	protein coding gene	Chr5:109612305-109621681 (+)
FVB/NJ	ENSMUSG00205051068	protein coding gene	Chr5:105481108-105490504 (+)
JF1/MsJ	ENSUMUG00000022413	protein coding gene	Chr5:112464744-112474193 (+)
LP/J	ENSMUSG00230046397	protein coding gene	Chr5:113731434-113740774 (+)
NOD/ShiLtJ	ENSMUSG00190047124	protein coding gene	Chr5:105517086-105526474 (+)
NZO/HlLtJ	ENSMUSG00225024551	protein coding gene	Chr5:121367920-121377314 (+)
PWK/PhJ	ENSLUMG00010024988	protein coding gene	Chr5:104374258-104383856 (+)
SPRET/EiJ	ENSMSPG00010044587	protein coding gene	Chr5:107633992-107643265 (+)
WSB/EiJ	ENSIUOG00005035269	protein coding gene	Chr5:108218170-108227548 (+)

Human Ortholog

TPST2, tyrosylprotein sulfotransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TPST2, tyrosylprotein sulfotransferase 2
Synonyms

TANGO13B, TPST-2
Links

HGNC:12021

NCBI Gene ID: 8459

UniProt: O60704
Chr Location

22q12.1; chr22:26521996-26596717 (-) GRCh38

MGI Vertebrate Homology

Tpst2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TPST2
Gene Tree

Tpst2

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

106
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

96
Radiation induced

1
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Tpst2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

105 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility.

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All GO Annotations

29
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

76

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tpst2

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All Sequences

77
RefSeq

13
UniProt

7
CCDS

CCDS19538.2

Ensembl

ENSMUSG00000029344 (Evidence)
NCBI Gene

22022

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029344	Ensembl Gene Model \| MGI Sequence Detail	38671	C57BL/6J	± kb
transcript	ENSMUST00000239473	Ensembl \| MGI Sequence Detail	1813	Not Applicable
polypeptide	ENSMUSP00000159350	Ensembl \| MGI Sequence Detail	390	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016595 protein-tyrosine sulfotransferase 2

(term hierarchy)
EC

2.8.2.20
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR026634 Protein-tyrosine sulfotransferase-like
GlyGen

O88856 2 sites, 1 N-linked glycan (1 site)

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All nucleic 78

Genomic 1

cDNA 76

Other 1

Microarray probesets 3

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MGD-MRK-16734, MGD-MRK-7379, MGI:2140887, MGI:93474, MGI:99932

Summaries

All 80

Gene Ontology 15

Phenotypes 35
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:338109 Dai D, et al., Enhanced tyrosine sulfation is associated with chronic kidney disease-related atherosclerosis. BMC Biol. 2023 Jul 10;21(1):151

TSS for Tpst2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47986	Chr5:112424549-112424559 (+)	-3 bp
Tssr47987	Chr5:112424560-112424622 (+)	34 bp
Tssr47988	Chr5:112424625-112424636 (+)	74 bp
Tssr47989	Chr5:112425322-112425347 (+)	778 bp
Tssr47990	Chr5:112433988-112434007 (+)	9,441 bp
Tssr47991	Chr5:112436600-112436634 (+)	12,060 bp
Tssr1593	Chr5:112439977-112439980 (+)	15,422 bp
Tssr1594	Chr5:112440042-112440049 (+)	15,489 bp
Tssr1595	Chr5:112440063-112440066 (+)	15,508 bp
Tssr47992	Chr5:112440091-112440127 (+)	15,552 bp
Tssr47993	Chr5:112440169-112440174 (+)	15,615 bp
Tssr47994	Chr5:112457686-112457729 (+)	33,151 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24