Tspan7 MGI Mouse Gene Detail - MGI:1298407

Symbol

Tspan7
Name

tetraspanin 7
Synonyms

1200014P11Rik, A15, Cd231, PE31, TALLA, Tm4sf2

Feature Type

protein coding gene
IDs

MGI:1298407
NCBI Gene: 21912
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:10351397-10462844 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 4.85 cM, cytoband A1.3-A2
Mapping Data

3 experiments

SNPs within 2kb

398 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298407	protein coding gene	ChrX:10351355-10462844 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035564	protein coding gene	ChrX:5230454-5342470 (+)
A/J	MGP_AJ_G0035541	protein coding gene	ChrX:5340049-5448665 (+)
AKR/J	MGP_AKRJ_G0035473	protein coding gene	ChrX:5426039-5538043 (+)
BALB/cJ	MGP_BALBcJ_G0035534	protein coding gene	ChrX:5242924-5356222 (+)
C3H/HeJ	MGP_C3HHeJ_G0035251	protein coding gene	ChrX:5363652-5478930 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036064	protein coding gene	ChrX:5327994-5440992 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032933	protein coding gene	ChrX:4396413-4498706 (+)
CAST/EiJ	MGP_CASTEiJ_G0034543	protein coding gene	ChrX:5059165-5168478 (+)
CBA/J	MGP_CBAJ_G0035220	protein coding gene	ChrX:5726238-5849546 (+)
DBA/2J	MGP_DBA2J_G0035373	protein coding gene	ChrX:5253701-5364125 (+)
FVB/NJ	MGP_FVBNJ_G0035320	protein coding gene	ChrX:5080387-5194371 (+)
LP/J	MGP_LPJ_G0035455	protein coding gene	ChrX:5440104-5548933 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035363	protein coding gene	ChrX:5649814-5767541 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036076	protein coding gene	ChrX:5158328-5271491 (+)
PWK/PhJ	MGP_PWKPhJ_G0034244	protein coding gene	ChrX:4741244-4846946 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034085	protein coding gene	ChrX:5225498-5335451 (+)
WSB/EiJ	MGP_WSBEiJ_G0034679	protein coding gene	ChrX:5229948-5340898 (+)

Human Ortholog

TSPAN7, tetraspanin 7

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSPAN7, tetraspanin 7
Synonyms

A15, CCG-B7, CD231, DXS1692E, MRX58, MXS1, TALLA-1, TM4SF2, TM4SF2b, XLID58
Links

HGNC:11854

NCBI Gene ID: 7102

neXtProt AC: NX_P41732

UniProt: P41732
Chr Location

Xp11.4; chrX:38561542-38688920 (+) GRCh38

MGI Vertebrate Homology

Tspan7 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSPAN7
Protein SuperFamily

Tetraspanin
Gene Tree

Tspan7

Diseases

1 with human TSPAN7 associations

				Human Disease	Mouse Models
				non-syndromic X-linked intellectual disability 58 IDs non-syndromic X-linked intellectual disability 58 DOID:0112024 OMIM:300210

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered hippocampal neurons, reduced mEPSC amplitudes and frequencies, reduced long term potentiation, reduced recognition of novel objects, impaired spatial working memory and spatial learning, and impaired associative memory.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

929
Tissues

59
cDNA Data

154
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tspan7

ZFIN tspan7

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All Sequences

48
RefSeq

4
UniProt

4
CCDS

CCDS30016.1

Ensembl

ENSMUSG00000058254 (Evidence)
NCBI Gene

21912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058254	Ensembl Gene Model \| MGI Sequence Detail	111448	C57BL/6J	± kb
transcript	ENSMUST00000076354	Ensembl \| MGI Sequence Detail	1733	Not Applicable
polypeptide	ENSMUSP00000075692	Ensembl \| MGI Sequence Detail	249	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016753 tetraspanin-7

(term hierarchy)
InterPro Domains

IPR048232 Tetraspanin-6/7, EC2 domain

IPR000301 Tetraspanin, animals

IPR018503 Tetraspanin, conserved site

IPR008952 Tetraspanin, EC2 domain superfamily

IPR018499 Tetraspanin/Peripherin

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All nucleic 154

cDNA 154

Microarray probesets 4

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MGI:1923526, MGI:2147872, MGI:2148083

Summaries

All 45

Developmental Gene Expression 8

Gene Ontology 3

Phenotypes 9
Earliest

J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Tspan7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160539	ChrX:10351360-10351402 (+)	-16 bp
Tssr160540	ChrX:10354062-10354070 (+)	2,669 bp
Tssr160541	ChrX:10384863-10384866 (+)	33,468 bp
Tssr160542	ChrX:10448373-10448376 (+)	96,978 bp
Tssr160543	ChrX:10448384-10448393 (+)	96,992 bp
Tssr160544	ChrX:10451788-10451811 (+)	100,403 bp
Tssr160545	ChrX:10461941-10462026 (+)	110,587 bp
Tssr160546	ChrX:10462243-10462269 (+)	110,859 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23