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Mcm7 Gene Detail
Summary
  • Symbol
    Mcm7
  • Name
    minichromosome maintenance complex component 7
  • Synonyms
    mCDC47, Mcmd7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298398
    NCBI Gene: 17220
  • Alliance
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr5:138162845-138170675 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 76.97 cM, cytoband G1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    81 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298398
protein coding gene Chr5:138162845-138170684 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030257
protein coding gene Chr5:142959664-142968405 (-)
A/J MGP_AJ_G0030225
protein coding gene Chr5:136778962-136786197 (-)
AKR/J MGP_AKRJ_G0030157
protein coding gene Chr5:141226286-141239449 (-)
BALB/cJ MGP_BALBcJ_G0030239
protein coding gene Chr5:138138582-138145801 (-)
C3H/HeJ MGP_C3HHeJ_G0029952
protein coding gene Chr5:141859044-141866884 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030686
protein coding gene Chr5:148313874-148321780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027904
protein coding gene Chr5:130913054-130920305 (-)
CAST/EiJ MGP_CASTEiJ_G0029358
protein coding gene Chr5:141238369-141247923 (-)
CBA/J MGP_CBAJ_G0029923
protein coding gene Chr5:154190682-154198522 (-)
DBA/2J MGP_DBA2J_G0030071
protein coding gene Chr5:136677831-136686251 (-)
FVB/NJ MGP_FVBNJ_G0030029
protein coding gene Chr5:135841153-135850668 (-)
LP/J MGP_LPJ_G0030160
protein coding gene Chr5:143495124-143508191 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030060
protein coding gene Chr5:157014420-157024042 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030727
protein coding gene Chr5:141067157-141074997 (-)
PWK/PhJ MGP_PWKPhJ_G0029072
protein coding gene Chr5:135737141-135744367 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028908
protein coding gene Chr5:138628085-138635731 (-)
WSB/EiJ MGP_WSBEiJ_G0029433
protein coding gene Chr5:141754400-141764430 (-)



Homology
more
  • Human Ortholog
    MCM7, minichromosome maintenance complex component 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCM7, minichromosome maintenance complex component 7
  • Synonyms
    CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
  • Links
    NCBI Gene ID: 4176
    neXtProt AC: NX_P33993
    UniProt: P33993

  • Chr Location
    7q22.1; chr7:100092728-100101940 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with human MCM7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17220 NCBI Gene Model | MGI Sequence Detail 7831 C57BL/6J ±  kb
transcript NM_001356577 RefSeq | MGI Sequence Detail 2722 C57BL/6  
polypeptide Q61881 UniProt | EBI | MGI Sequence Detail 719 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 170
    cDNA 165
    Primer pair 3
    Other 2

    Microarray probesets 4
References
more
  • Summaries
    All 66
    Developmental Gene Expression 12
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:30650 Takizawa N, et al., Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Gene. 1995 Dec 29;167(1-2):343-4
  • Latest
    J:342644 Tscherner AK, et al., Relationship of quantitative reverse transcription polymerase chain reaction (RT-PCR) to RNA Sequencing (RNAseq) transcriptome identifies mouse preimplantation embryo reference genes. Biol Reprod. 2023 Nov 15;109(5):601-617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/20/2024
MGI 6.23
The Jackson Laboratory