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Matr3 Gene Detail
Summary
  • Symbol
    Matr3
  • Name
    matrin 3
  • Synonyms
    1110061A14Rik, 2810017I02Rik, D030046F20Rik, mKIAA0723
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298379
    NCBI Gene: 17184
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35695191-35726888 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.14 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    484 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298379
 protein coding gene Chr18:35686462-35726888 (+)
129S1/SvImJ ENSMUSG00200041127
 protein coding gene Chr18:32703654-32704301 (+)
129S1/SvImJ ENSMUSGG00200054622
 protein coding gene Chr18:32704578-32727637 (+)
A/J ENSMUSG00195032033
 protein coding gene Chr18:32870374-32871021 (+)
A/J ENSMUSGG00195055075
 protein coding gene Chr18:32871298-32894354 (+)
AKR/J ENSMUSG00220015910
 protein coding gene Chr18:32846691-32847338 (+)
AKR/J ENSMUSGG00220054354
 protein coding gene Chr18:32847615-32870675 (+)
BALB/cJ ENSMUSG00180019111
 protein coding gene Chr18:33320009-33320656 (+)
BALB/cJ ENSMUSGG00180055205
 protein coding gene Chr18:33320933-33341214 (+)
C3H/HeJ ENSMUSGG00175054616
 protein coding gene Chr18:32828482-32848781 (+)
C3H/HeJ ENSMUSG00175032831
 protein coding gene Chr18:32827558-32828205 (+)
C57BL/6NJ ENSMUSG00215012627
 protein coding gene Chr18:32573762-32574409 (+)
C57BL/6NJ ENSMUSGG00215055321
 protein coding gene Chr18:32574686-32597744 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022108
 protein coding gene Chr18:32826819-32857340 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054644
 protein coding gene Chr18:32863095-32886150 (+)
CBA/J ENSMUSG00210020208
 protein coding gene Chr18:32862171-32862818 (+)
DBA/2J ENSMUSGG00185057490
 protein coding gene Chr18:32797658-32820713 (+)
DBA/2J ENSMUSG00185018386
 protein coding gene Chr18:32796734-32797381 (+)
FVB/NJ ENSMUSG00205017016
 protein coding gene Chr18:32508552-32509199 (+)
FVB/NJ ENSMUSGG00205054518
 protein coding gene Chr18:32509476-32532533 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230045656
 protein coding gene Chr18:34900465-34901112 (+)
LP/J ENSMUSGG00230055520
 protein coding gene Chr18:34901389-34924448 (+)
NOD/ShiLtJ ENSMUSG00190018074
 protein coding gene Chr18:32581380-32582027 (+)
NOD/ShiLtJ ENSMUSGG00190054732
 protein coding gene Chr18:32582304-32602625 (+)
NZO/HlLtJ ENSMUSG00225043808
 protein coding gene Chr18:34805270-34805917 (+)
NZO/HlLtJ ENSMUSGG00225055626
 protein coding gene Chr18:34806194-34829249 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010019556
 protein coding gene Chr18:33136824-33175969 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    MATR3, matrin 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATR3, matrin 3
  • Synonyms
    ALS21, MPD2, VCPDM
  • Links
    NCBI Gene ID: 9782
    UniProt: P43243

  • Chr Location
    5q31.2; chr5:139273752-139331677 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Matr3 mouse models; 1 with human MATR3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele are early embryonic lethal. Heterozygotes show congenital heart defects including abnormal heart apex morphology, subaortic ventricular septal defects, double-outlet right ventricle, bicuspid aortic valve, aorta coarctation, and patent ductus arteriosus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    701
  • Tissues
    63
  • cDNA Data
    27
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037236 Ensembl Gene Model | MGI Sequence Detail 31698 C57BL/6J ±  kb
    transcript ENSMUST00000166793 Ensembl | MGI Sequence Detail 6262 Not Applicable  
    polypeptide ENSMUSP00000125761 Ensembl | MGI Sequence Detail 846 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 28
      Primer pair 4
      Other 1
      Antibodies 5

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1916077, MGI:1917217, MGI:2147265, MGI:2147377, MGI:3026954
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:49740 Matsushima Y, et al., Cloning and genomic mapping of the mouse matrin 3 gene and its pseudogenes. Cytogenet Cell Genet. 1998;81(3-4):194-8
    • Latest
      J:363755 Cheng X, et al., Liver matrin-3 protects mice against hepatic steatosis and stress response via constitutive androstane receptor. Mol Metab. 2024 Aug;86:101977
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory