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Matr3 Gene Detail
Summary
  • Symbol
    Matr3
  • Name
    matrin 3
  • Synonyms
    1110061A14Rik, 2810017I02Rik, D030046F20Rik, mKIAA0723
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298379
    NCBI Gene: 17184
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35695211-35725098 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.14 cM, cytoband C
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298379
 protein coding gene Chr18:35695191-35726888 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024261
 protein coding gene Chr18:33864171-33907022 (+)
A/J MGP_AJ_G0024227
 protein coding gene Chr18:32693426-32732652 (+)
AKR/J MGP_AKRJ_G0024195
 protein coding gene Chr18:33614610-33649106 (+)
BALB/cJ MGP_BALBcJ_G0024227
 protein coding gene Chr18:32749798-32789778 (+)
C3H/HeJ MGP_C3HHeJ_G0023994
 protein coding gene Chr18:33658466-33692020 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024668
 protein coding gene Chr18:35098000-35126461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022108
 protein coding gene Chr18:32826819-32857340 (+)
CAST/EiJ MGP_CASTEiJ_G0023469
 protein coding gene Chr18:33652275-33680658 (+)
CBA/J MGP_CBAJ_G0023962
 protein coding gene Chr18:36103849-36139185 (+)
DBA/2J MGP_DBA2J_G0024094
 protein coding gene Chr18:32342407-32376842 (+)
FVB/NJ MGP_FVBNJ_G0024061
 protein coding gene Chr18:32030035-32062473 (+)
LP/J MGP_LPJ_G0024176
 protein coding gene Chr18:33929842-33959435 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024089
 protein coding gene Chr18:37345676-37376068 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024717
 protein coding gene Chr18:33467437-33498339 (+)
PWK/PhJ MGP_PWKPhJ_G0023213
 protein coding gene Chr18:32570499-32599566 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023020
 protein coding gene Chr18:33737500-33767642 (+)
WSB/EiJ MGP_WSBEiJ_G0023532
 protein coding gene Chr18:33388458-33422969 (+)



Homology
more
  • Human Ortholog
    MATR3, matrin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MATR3, matrin 3
  • Synonyms
    ALS21, MPD2, VCPDM
  • Links
    NCBI Gene ID: 9782
    neXtProt AC: NX_P43243
    UniProt: P43243

  • Chr Location
    5q31.2; chr5:139273752-139331677 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Matr3 mouse models; 1 with human MATR3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele are early embryonic lethal. Heterozygotes show congenital heart defects including abnormal heart apex morphology, subaortic ventricular septal defects, double-outlet right ventricle, bicuspid aortic valve, aorta coarctation, and patent ductus arteriosus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    59
  • cDNA Data
    27
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17184 NCBI Gene Model | MGI Sequence Detail 29888 C57BL/6J ±  kb
    transcript NM_001399986 RefSeq | MGI Sequence Detail 4078 C57BL/6  
    polypeptide Q8K310 UniProt | EBI | MGI Sequence Detail 846 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 28
      Primer pair 4
      Other 1

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGI:1916077, MGI:1917217, MGI:2147265, MGI:2147377, MGI:3026954
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:49740 Matsushima Y, et al., Cloning and genomic mapping of the mouse matrin 3 gene and its pseudogenes. Cytogenet Cell Genet. 1998;81(3-4):194-8
    • Latest
      J:298091 Kao CS, et al., Selective neuronal degeneration in MATR3 S85C knock-in mouse model of early-stage ALS. Nat Commun. 2020 Oct 20;11(1):5304
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/24/2023
    MGI 6.22     		The Jackson Laboratory