Eipr1 MGI Mouse Gene Detail - MGI:1289332 - EARP complex and GARP complex interacting protein 1

Symbol

Eipr1
Name

EARP complex and GARP complex interacting protein 1
Synonyms

D12Ertd604e, Tssc1

Feature Type

protein coding gene
IDs

MGI:1289332
NCBI Gene: 380752
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:28801801-28917493 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 11.26 cM
Mapping Data

2 experiments

SNPs within 2kb

1481 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289332	protein coding gene	Chr12:28801801-28919864 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019647	protein coding gene	Chr12:26594130-26714066 (+)
A/J	MGP_AJ_G0019614	protein coding gene	Chr12:25880807-25995145 (+)
AKR/J	MGP_AKRJ_G0019585	protein coding gene	Chr12:26752337-26869624 (+)
BALB/cJ	MGP_BALBcJ_G0019591	protein coding gene	Chr12:26128422-26245132 (+)
C3H/HeJ	MGP_C3HHeJ_G0019395	protein coding gene	Chr12:26597415-26715941 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020038	protein coding gene	Chr12:27449141-27573473 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017663	protein coding gene	Chr12:25230614-25348530 (+)
CAST/EiJ	MGP_CASTEiJ_G0018950	protein coding gene	Chr12:21560858-21673011 (+)
CBA/J	MGP_CBAJ_G0019366	protein coding gene	Chr12:28418312-28537144 (+)
DBA/2J	MGP_DBA2J_G0019480	protein coding gene	Chr12:25730050-25843536 (+)
FVB/NJ	MGP_FVBNJ_G0019471	protein coding gene	Chr12:25531340-25644591 (+)
LP/J	MGP_LPJ_G0019550	protein coding gene	Chr12:26682873-26804555 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019506	protein coding gene	Chr12:28045318-28167153 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020078	protein coding gene	Chr12:26261980-26377001 (+)
PWK/PhJ	MGP_PWKPhJ_G0018717	protein coding gene	Chr12:20434618-20553042 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018505	protein coding gene	Chr12:20844164-20963315 (+)
WSB/EiJ	MGP_WSBEiJ_G0019001	protein coding gene	Chr12:26458993-26578773 (+)

Human Ortholog

EIPR1, EARP complex and GARP complex interacting protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIPR1, EARP complex and GARP complex interacting protein 1
Synonyms

EIPR-1, TSSC1
Links

HGNC:12383

NCBI Gene ID: 7260

neXtProt AC: NX_Q53HC9

UniProt: Q53HC9
Chr Location

2p25.3; chr2:3188968-3377882 (-) GRCh38.p7

Alliance of Genome Resources

Eipr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIPR1
Gene Tree

Eipr1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

9
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eipr1

ZFIN eipr1

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Eipr1 interacts with 68 markers (Mir23a, Mir29b-1, Mir30a, ...) View All

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All Sequences

60
RefSeq

14
UniProt

4
CCDS

CCDS25855.1

Ensembl

ENSMUSG00000036613 (Evidence)
NCBI Gene

380752

			Length	Strain/Species	Flank
genomic	380752	NCBI Gene Model \| MGI Sequence Detail	115693	C57BL/6J	± kb
transcript	NM_001379229	RefSeq \| MGI Sequence Detail	1783	C57BL/6
polypeptide	Q8K0G5	UniProt \| EBI \| MGI Sequence Detail	386	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016768 EARP and GARP complex-interacting protein 1

(term hierarchy)
InterPro Domains

IPR040323 EARP and GARP complex-interacting protein 1

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 6

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:233672 Topalidou I, et al., The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. PLoS Genet. 2016 May;12(5):e1006074

TSS for Eipr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113052	Chr12:28801797-28801867 (+)	31 bp
Tssr3815	Chr12:28850696-28850708 (+)	48,901 bp
Tssr113054	Chr12:28852220-28852224 (+)	50,421 bp
Tssr113055	Chr12:28884700-28884713 (+)	82,906 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/09/2023 MGI 6.22