Dop1a MGI Mouse Gene Detail - MGI:1289294 - DOP1 leucine zipper like protein A

Symbol

Dop1a
Name

DOP1 leucine zipper like protein A
Synonyms

B130005I07Rik, D9Ertd809e, Dopey1

Feature Type

protein coding gene
IDs

MGI:1289294
NCBI Gene: 320615
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr9:86349194-86436683 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 46.58 cM
Mapping Data

3 experiments

SNPs within 2kb

692 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289294	protein coding gene	Chr9:86349194-86437976 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035095	protein coding gene	Chr9:87289103-87385683 (+)
A/J	MGP_AJ_G0035076	protein coding gene	Chr9:84239228-84340805 (+)
AKR/J	MGP_AKRJ_G0035004	protein coding gene	Chr9:86242187-86331753 (+)
BALB/cJ	MGP_BALBcJ_G0035064	protein coding gene	Chr9:83879957-83976919 (+)
C3H/HeJ	MGP_C3HHeJ_G0034776	protein coding gene	Chr9:86701871-86794033 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035588	protein coding gene	Chr9:89636547-89739757 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032495	protein coding gene	Chr9:83026122-83100880 (+)
CAST/EiJ	MGP_CASTEiJ_G0034094	protein coding gene	Chr9:87179432-87270513 (+)
CBA/J	MGP_CBAJ_G0034749	protein coding gene	Chr9:92845245-92931275 (+)
DBA/2J	MGP_DBA2J_G0034907	protein coding gene	Chr9:83787231-83881534 (+)
FVB/NJ	MGP_FVBNJ_G0034850	protein coding gene	Chr9:82901807-82988602 (+)
LP/J	MGP_LPJ_G0034988	protein coding gene	Chr9:87506509-87598007 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034892	protein coding gene	Chr9:94423460-94518678 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035608	protein coding gene	Chr9:86354348-86442591 (+)
PWK/PhJ	MGP_PWKPhJ_G0033798	protein coding gene	Chr9:83977228-84065411 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033634	protein coding gene	Chr9:86558527-86654225 (+)
WSB/EiJ	MGP_WSBEiJ_G0034211	protein coding gene	Chr9:86384811-86477726 (+)

Human Ortholog

DOP1A, DOP1 leucine zipper like protein A

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOP1A, DOP1 leucine zipper like protein A
Synonyms

dJ202D23.2, DOP1, DOPEY1, KIAA1117
Links

HGNC:21194

NCBI Gene ID: 23033

neXtProt AC: NX_Q5JWR5

UniProt: Q5JWR5
Chr Location

6q14.1; chr6:83067666-83171350 (+) GRCh38

Alliance of Genome Resources

Dop1a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOP1A
Gene Tree

Dop1a

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Dop1a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

63 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development	DNA-templated transcription

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

4
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dop1a

ZFIN dop1a

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Dop1a interacts with 310 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

112
RefSeq

39
UniProt

9
CCDS

CCDS52876.1

Ensembl

ENSMUSG00000034973 (Evidence)
NCBI Gene

320615

			Length	Strain/Species	Flank
genomic	320615	NCBI Gene Model \| MGI Sequence Detail	87490	C57BL/6J	± kb
transcript	NM_177208	RefSeq \| MGI Sequence Detail	7908	ZRU/MplStud
polypeptide	Q8BL99	UniProt \| EBI \| MGI Sequence Detail	2399	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000006639 protein dopey-1

(term hierarchy)
InterPro Domains

IPR007249 Dopey, N-terminal

IPR040314 Protein dopey

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All nucleic 23

cDNA 19

Primer pair 4

Microarray probesets 3

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MGI:2444370, MGI:2449769

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:281311 Nakano Y, et al., Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Cell Rep. 2019 Apr 16;27(3):860-871.e8

TSS for Dop1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86391	Chr9:86349216-86349223 (+)	26 bp
Tssr86392	Chr9:86349226-86349272 (+)	55 bp
Tssr86393	Chr9:86349277-86349314 (+)	102 bp
Tssr2956	Chr9:86350012-86350017 (+)	821 bp
Tssr86394	Chr9:86389181-86389185 (+)	39,989 bp
Tssr86395	Chr9:86427283-86427295 (+)	78,095 bp
Tssr86396	Chr9:86427309-86427322 (+)	78,122 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/21/2023 MGI 6.22