Txndc17 MGI Mouse Gene Detail - MGI:1289248 - thioredoxin domain containing 17

Symbol

Txndc17
Name

thioredoxin domain containing 17
Synonyms

4831443O22Rik, D11Ertd672e, TRP14, Txnl5

Feature Type

protein coding gene
IDs

MGI:1289248
NCBI Gene: 52700
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:72098373-72100841 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.92 cM
Mapping Data

3 experiments

SNPs within 2kb

53 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1289248	protein coding gene	Chr11:72098373-72101313 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018632	protein coding gene	Chr11:72825447-72827913 (+)
A/J	MGP_AJ_G0018600	protein coding gene	Chr11:70099988-70102454 (+)
AKR/J	MGP_AKRJ_G0018569	protein coding gene	Chr11:72232993-72235461 (+)
BALB/cJ	MGP_BALBcJ_G0018572	protein coding gene	Chr11:70394773-70397241 (+)
C3H/HeJ	MGP_C3HHeJ_G0018385	protein coding gene	Chr11:72194330-72196798 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019023	protein coding gene	Chr11:75023507-75025975 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016666	protein coding gene	Chr11:66941102-66943559 (+)
CAST/EiJ	MGP_CASTEiJ_G0017940	protein coding gene	Chr11:72567329-72569795 (+)
CBA/J	MGP_CBAJ_G0018357	protein coding gene	Chr11:78347361-78349829 (+)
DBA/2J	MGP_DBA2J_G0018466	protein coding gene	Chr11:69750070-69752558 (+)
FVB/NJ	MGP_FVBNJ_G0018457	protein coding gene	Chr11:69274419-69276887 (+)
LP/J	MGP_LPJ_G0018537	protein coding gene	Chr11:73333287-73335753 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018480	protein coding gene	Chr11:78924135-78926603 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019065	protein coding gene	Chr11:72437562-72440028 (+)
PWK/PhJ	MGP_PWKPhJ_G0017713	protein coding gene	Chr11:70362142-70364631 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017503	protein coding gene	Chr11:72143874-72146350 (+)
WSB/EiJ	MGP_WSBEiJ_G0017994	protein coding gene	Chr11:72176166-72178632 (+)

Human Ortholog

TXNDC17, thioredoxin domain containing 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TXNDC17, thioredoxin domain containing 17
Synonyms

TRP14, TXNL5
Links

HGNC:28218

NCBI Gene ID: 84817

neXtProt AC: NX_Q9BRA2

UniProt: Q9BRA2
Chr Location

17p13.1; chr17:6640985-6644541 (+) GRCh38

MGI Vertebrate Homology

Txndc17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TXNDC17
Gene Tree

Txndc17

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Phenotype Summary

11 phenotype references

All Mutations and Alleles

5
Chemically induced (other)

1
Targeted

4
Genomic Mutations

2 involving Txndc17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

83

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase txndc17

ZFIN txndc17

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All Sequences

42
RefSeq

2
UniProt

1
CCDS

CCDS24980.1

Ensembl

ENSMUSG00000020803 (Evidence)
NCBI Gene

52700

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020803	Ensembl Gene Model \| MGI Sequence Detail	2469	C57BL/6J	± kb
transcript	ENSMUST00000021158	Ensembl \| MGI Sequence Detail	981	Not Applicable
polypeptide	ENSMUSP00000021158	Ensembl \| MGI Sequence Detail	123	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016859 thioredoxin domain-containing protein 17

(term hierarchy)
PDB

1V9W
InterPro Domains

IPR045108 Thioredoxin domain-containing protein 17-like

IPR010357 Thioredoxin domain-containing protein 17-like domain

IPR036249 Thioredoxin-like superfamily

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All nucleic 84

cDNA 83

Primer pair 1

Microarray probesets 5

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MGI:1915352

Summaries

All 39

Gene Ontology 4

Phenotypes 11
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:283042 Doka E, et al., Control of protein function through oxidation and reduction of persulfidated states. Sci Adv. 2020 Jan;6(1):eaax8358

TSS for Txndc17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102820	Chr11:72098347-72098358 (+)	-20 bp
Tssr102821	Chr11:72098363-72098446 (+)	32 bp
Tssr102822	Chr11:72099093-72099110 (+)	729 bp
Tssr102823	Chr11:72099558-72099586 (+)	1,199 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23