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Il13ra2 Gene Detail
Summary
  • Symbol
    Il13ra2
  • Name
    interleukin 13 receptor, alpha 2
  • Synonyms
    CD213a2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277954
    NCBI Gene: 16165
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:146166472-146212188 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277954
 protein coding gene ChrX:146166472-146214982 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036164
 protein coding gene ChrX:144994916-145041946 (-)
A/J MGP_AJ_G0036141
 protein coding gene ChrX:144253139-144302694 (-)
AKR/J MGP_AKRJ_G0036067
 protein coding gene ChrX:149013910-149070487 (-)
BALB/cJ MGP_BALBcJ_G0036132
 protein coding gene ChrX:142473065-142518227 (-)
C3H/HeJ MGP_C3HHeJ_G0035840
 protein coding gene ChrX:145114477-145161401 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036656
 protein coding gene ChrX:149089984-149138259 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033481
 protein coding gene ChrX:135701502-135742335 (-)
CAST/EiJ MGP_CASTEiJ_G0035131
 protein coding gene ChrX:125639415-125673470 (-)
CBA/J MGP_CBAJ_G0035817
 protein coding gene ChrX:153728143-153777128 (-)
DBA/2J MGP_DBA2J_G0035975
 protein coding gene ChrX:143309577-143356383 (-)
FVB/NJ MGP_FVBNJ_G0035909
 protein coding gene ChrX:142532930-142578661 (-)
LP/J MGP_LPJ_G0036066
 protein coding gene ChrX:145908382-145954844 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035945
 protein coding gene ChrX:161847504-161892571 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036692
 protein coding gene ChrX:144259972-144307769 (-)
PWK/PhJ MGP_PWKPhJ_G0034825
 protein coding gene ChrX:122392430-122438923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034651
 protein coding gene ChrX:126207418-126254879 (-)
WSB/EiJ MGP_WSBEiJ_G0035266
 protein coding gene ChrX:142560811-142606942 (-)



Homology
more
  • Human Ortholog
    IL13RA2, interleukin 13 receptor subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL13RA2, interleukin 13 receptor subunit alpha 2
  • Synonyms
    CD213A2, CT19, IL13BP, IL-13R
  • Links
    NCBI Gene ID: 3598
    neXtProt AC: NX_Q14627
    UniProt: Q14627

  • Chr Location
    Xq23; chrX:115003975-115019977 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IL13RA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mice display a phenotype consistent with attenuated IL13 responsiveness, including abnormal serum protein concentrations, increased frequency of bone marrow macrophage progenitor cells, and abnormal response of tissue macrophage to LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    13
  • cDNA Data
    5
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031289 Ensembl Gene Model | MGI Sequence Detail 45717 C57BL/6J ±  kb
    transcript ENSMUST00000033646 Ensembl | MGI Sequence Detail 2281 Not Applicable  
    polypeptide ENSMUSP00000033646 Ensembl | MGI Sequence Detail 383 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 5
      Primer pair 3
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:49271 Donaldson DD, et al., The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol. 1998 Sep 1;161(5):2317-24
    • Latest
      J:338821 Li R, et al., TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 Aug 1;14(1):4605
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory