Zfp644 MGI Mouse Gene Detail - MGI:1277212

Symbol

Zfp644
Name

zinc finger protein 644
Synonyms

1110068L01Rik, BM-005, D5Ertd689e, mKIAA1221, Zep-2

Feature Type

protein coding gene
IDs

MGI:1277212
NCBI Gene: 52397
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:106764605-106844696 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 51.43 cM
Mapping Data

3 experiments

SNPs within 2kb

1567 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277212	protein coding gene	Chr5:106764605-106845153 (-)
129S1/SvImJ	ENSMUSG00200005832	protein coding gene	Chr5:100498802-100578857 (-)
A/J	ENSMUSG00195032682	protein coding gene	Chr5:99961085-100041131 (-)
AKR/J	ENSMUSG00220036515	protein coding gene	Chr5:99517411-99597467 (-)
BALB/cJ	ENSMUSG00180030725	protein coding gene	Chr5:100113210-100193254 (-)
C3H/HeJ	ENSMUSG00175045909	protein coding gene	Chr5:102151943-102232027 (-)
C57BL/6NJ	ENSMUSG00215013902	protein coding gene	Chr5:100166516-100246612 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027495	protein coding gene	Chr5:99517407-99597783 (-)
CAST/EiJ	ENSTCUG00005022290	protein coding gene	Chr5:99384687-99465819 (-)
CBA/J	ENSMUSG00210033351	protein coding gene	Chr5:100909559-100989645 (-)
DBA/2J	ENSMUSG00185046723	protein coding gene	Chr5:103823039-103903070 (-)
FVB/NJ	ENSMUSG00205021241	protein coding gene	Chr5:99838307-99918387 (-)
JF1/MsJ	ENSUMUG00000008058	protein coding gene	Chr5:106870253-106950646 (-)
LP/J	ENSMUSG00230028139	protein coding gene	Chr5:108040060-108120109 (-)
NOD/ShiLtJ	ENSMUSG00190022149	protein coding gene	Chr5:99834700-99914756 (-)
NZO/HlLtJ	ENSMUSG00225025406	protein coding gene	Chr5:115661788-115741837 (-)
PWK/PhJ	ENSLUMG00010013260	protein coding gene	Chr5:98875523-98955649 (-)
SPRET/EiJ	ENSMSPG00010045298	protein coding gene	Chr5:101967535-102044679 (-)
WSB/EiJ	ENSIUOG00005029200	protein coding gene	Chr5:102549206-102629245 (-)

Human Ortholog

ZNF644, zinc finger protein 644

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF644, zinc finger protein 644
Synonyms

BM-005, MYP21, NatF, ZEP-2
Links

HGNC:29222

NCBI Gene ID: 84146

UniProt: Q9H582
Chr Location

1p22.2; chr1:90915298-91022376 (-) GRCh38

MGI Vertebrate Homology

Zfp644 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ZNF644
Gene Tree

Zfp644

Diseases

1 with human ZNF644 associations

				Human Disease	Mouse Models
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Zfp644
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit normal blood lymphocyte populations.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

605
Tissues

8
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ZNF644

Xenbase znf644

ZFIN znf644a, znf644b

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All Sequences

189
RefSeq

105
UniProt

15
CCDS

CCDS39196.1

Ensembl

ENSMUSG00000049606 (Evidence)
NCBI Gene

52397

			Length	Strain/Species	Flank
genomic	52397	NCBI Gene Model \| MGI Sequence Detail	80092	C57BL/6J	± kb
transcript	NM_001363318	RefSeq \| MGI Sequence Detail	6064	ZRU/MplStud
polypeptide	NP_001350247	RefSeq \| MGI Sequence Detail	1292	ZRU/MplStud

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UniProt

15 Sequences
InterPro Domains

IPR051643 Transcriptional Regulators with Zinc Finger Domains

IPR055125 Wiz, C-terminal zinc finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

E9QA22 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 13

Primer pair 2

Microarray probesets 6

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MGI:1916116, MGI:2140743

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp644:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52353	Chr5:106844685-106844705 (-)	1 bp
Tssr52352	Chr5:106844654-106844682 (-)	28 bp
Tssr52351	Chr5:106844625-106844650 (-)	58 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24