Ptp4a3 MGI Mouse Gene Detail - MGI:1277098 - protein tyrosine phosphatase 4a3

Symbol

Ptp4a3
Name

protein tyrosine phosphatase 4a3
Synonyms

Prl-3

Feature Type

protein coding gene
IDs

MGI:1277098
NCBI Gene: 19245
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr15:73594991-73629075 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.05 cM, cytoband E1
Mapping Data

3 experiments

SNPs within 2kb

413 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1277098	protein coding gene	Chr15:73594991-73630615 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021924	protein coding gene	Chr15:73478805-73519609 (+)
A/J	MGP_AJ_G0021883	protein coding gene	Chr15:70852766-70888385 (+)
AKR/J	MGP_AKRJ_G0021865	protein coding gene	Chr15:72655855-72693134 (+)
BALB/cJ	MGP_BALBcJ_G0021890	protein coding gene	Chr15:70857554-70894072 (+)
C3H/HeJ	MGP_C3HHeJ_G0021663	protein coding gene	Chr15:72811406-72848132 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022330	protein coding gene	Chr15:76269407-76309219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019866	protein coding gene	Chr15:67273071-67308564 (+)
CAST/EiJ	MGP_CASTEiJ_G0021182	protein coding gene	Chr15:73612787-73648592 (+)
CBA/J	MGP_CBAJ_G0021629	protein coding gene	Chr15:78763047-78801576 (+)
DBA/2J	MGP_DBA2J_G0021754	protein coding gene	Chr15:70451204-70487483 (+)
FVB/NJ	MGP_FVBNJ_G0021736	protein coding gene	Chr15:69472439-69509434 (+)
LP/J	MGP_LPJ_G0021826	protein coding gene	Chr15:73503475-73540181 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021759	protein coding gene	Chr15:84118259-84154012 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022351	protein coding gene	Chr15:73052465-73088180 (+)
PWK/PhJ	MGP_PWKPhJ_G0020923	protein coding gene	Chr15:70550455-70586594 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020764	protein coding gene	Chr15:72944520-72980201 (+)
WSB/EiJ	MGP_WSBEiJ_G0021234	protein coding gene	Chr15:73055005-73090723 (+)

Human Ortholog

PTP4A3, protein tyrosine phosphatase 4A3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTP4A3, protein tyrosine phosphatase 4A3
Synonyms

PRL3, PRL-3, PRL-R
Links

HGNC:9636

NCBI Gene ID: 11156

neXtProt AC: NX_O75365

UniProt: O75365
Chr Location

8q24.3; chr8:141391995-141432454 (+) GRCh38

MGI Vertebrate Homology

Ptp4a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTP4A3
Gene Tree

Ptp4a3

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

3
Endonuclease-mediated

2
Gene trapped

9
Radiation induced

2
Targeted

6
Genomic Mutations

5 involving Ptp4a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial preweaning lethality and decreased incidence of AOM-DDS induced tumors. Mice homozygous for a different targeted allele exhibit decreased circulating glucose levels in an intraperitoneal glucose tolerance test.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

37
cDNA Data

94
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptp4a3

ZFIN ptp4a3a

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All Sequences

83
RefSeq

21
UniProt

4
CCDS

CCDS27519.1, CCDS49633.1

Ensembl

ENSMUSG00000059895 (Evidence)
NCBI Gene

19245

			Length	Strain/Species	Flank
genomic	19245	NCBI Gene Model \| MGI Sequence Detail	34085	C57BL/6J	± kb
transcript	NM_001166388	RefSeq \| MGI Sequence Detail	2430	C57BL/6
polypeptide	Q9D658	UniProt \| EBI \| MGI Sequence Detail	173	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013442 protein tyrosine phosphatase type IVA 3

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR020422 Dual specificity protein phosphatase domain

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 96

cDNA 95

Primer pair 1

Microarray probesets 4

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MGI:2146167

Summaries

All 72

Developmental Gene Expression 6

Diseases 1

Gene Ontology 8

Phenotypes 35
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:325252 Hou S, et al., Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals. Cell Res. 2022 Apr;32(4):333-348

TSS for Ptp4a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131537	Chr15:73594973-73594978 (+)	-15 bp
Tssr131538	Chr15:73594980-73595000 (+)	-1 bp
Tssr4623	Chr15:73595005-73595008 (+)	16 bp
Tssr131539	Chr15:73595013-73595023 (+)	27 bp
Tssr131540	Chr15:73596603-73596675 (+)	1,648 bp
Tssr131543	Chr15:73614705-73614708 (+)	19,716 bp
Tssr131544	Chr15:73620214-73620233 (+)	25,233 bp
Tssr131545	Chr15:73620265-73620267 (+)	25,275 bp
Tssr131546	Chr15:73621431-73621445 (+)	26,447 bp
Tssr131547	Chr15:73622627-73622632 (+)	27,639 bp
Tssr131548	Chr15:73623158-73623174 (+)	28,175 bp
Tssr131549	Chr15:73623242-73623251 (+)	28,256 bp
Tssr4624	Chr15:73623264-73623288 (+)	28,285 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23