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H2-M10.4 Gene Detail
Summary
  • Symbol
    H2-M10.4
  • Name
    histocompatibility 2, M region locus 10.4
  • Synonyms
    15H
Location &
Maps
more
  • Sequence Map
    Chr17:36769809-36773221 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.09 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276527
 protein coding gene Chr17:36769809-36773226 (-)
129S1/SvImJ ENSMUSG00200047753
 protein coding gene Chr17:32249297-32252714 (-)
A/J ENSMUSG00195033268
 protein coding gene Chr17:33457007-33460424 (-)
AKR/J ENSMUSG00220052049
 protein coding gene Chr17:32246905-32250322 (-)
BALB/cJ ENSMUSG00180032950
 protein coding gene Chr17:32911486-32914903 (-)
C3H/HeJ ENSMUSG00175036551
 protein coding gene Chr17:32134545-32137962 (-)
C57BL/6NJ ENSMUSG00215053051
 protein coding gene Chr17:32063083-32066500 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021551
 protein coding gene Chr17:33485001-33488427 (-)
CAST/EiJ ENSTCUG00005050493
 protein coding gene Chr17:33298547-33301964 (-)
CBA/J ENSMUSG00210052001
 protein coding gene Chr17:31956343-31959760 (-)
DBA/2J ENSMUSG00185052698
 protein coding gene Chr17:34892459-34895876 (-)
FVB/NJ ENSMUSG00205029135
 protein coding gene Chr17:32513775-32517192 (-)
JF1/MsJ ENSUMUG00000034536
 protein coding gene Chr17:33834386-33837802 (-)
LP/J ENSMUSG00230053671
 protein coding gene Chr17:36044668-36048085 (-)
NOD/ShiLtJ ENSMUSG00190036463
 protein coding gene Chr17:32132230-32135647 (-)
NZO/HlLtJ ENSMUSG00225052782
 protein coding gene Chr17:37966718-37970135 (-)
PWK/PhJ ENSLUMG00010043494
 protein coding gene Chr17:31720935-31724352 (-)
SPRET/EiJ ENSMSPG00010049845
 protein coding gene Chr17:33004677-33006850 (-)
WSB/EiJ ENSIUOG00005047677
 protein coding gene Chr17:33024424-33027841 (-)



Homology
more
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353867-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722738-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-H, major histocompatibility complex, class I, H (pseudogene)
  • Synonyms
    HLAHP
  • Links
    NCBI Gene ID: 3136
    UniProt: P01893

  • Chr Location
    6p22.1; chr6:29887565-29924658 (+)  GRCh38
Human Diseases
more
  • Diseases
    46 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    38
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 224753 NCBI Gene Model | MGI Sequence Detail 3413 C57BL/6J ±  kb
transcript NM_177634 RefSeq | MGI Sequence Detail 1448 ZRU/MplStud  
polypeptide NP_808302 RefSeq | MGI Sequence Detail 331 ZRU/MplStud  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • PDB
    1ZS8
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
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  • All nucleic 4
    Genomic 3
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 18
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:45971 Arepalli SR, et al., Characterization of two class I genes from the H2-M region: evidence for a new subfamily. Immunogenetics. 1998;47(3):264-71
  • Latest
    J:207447 Leinders-Zufall T, et al., A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J Neurosci. 2014 Apr 9;34(15):5121-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory