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Cry2 Gene Detail
Summary
  • Symbol
    Cry2
  • Name
    cryptochrome circadian regulator 2
  • Synonyms
    D130054K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270859
    NCBI Gene: 12953
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Regulated by
    Rr472 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr2:92233991-92264388 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 51.01 cM, cytoband E
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    820 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270859
 protein coding gene Chr2:92233991-92264426 (-)
129S1/SvImJ ENSMUSG00200052266
 protein coding gene Chr2:89150361-89180760 (-)
A/J ENSMUSG00195053115
 protein coding gene Chr2:89285811-89316199 (-)
AKR/J ENSMUSG00220049386
 protein coding gene Chr2:89080578-89110969 (-)
BALB/cJ ENSMUSG00180054614
 protein coding gene Chr2:89185069-89215469 (-)
C3H/HeJ ENSMUSG00175053750
 protein coding gene Chr2:89445250-89475644 (-)
C57BL/6NJ ENSMUSG00215052597
 protein coding gene Chr2:89277577-89307976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023980
 protein coding gene Chr2:86529526-86561488 (-)
CAST/EiJ ENSTCUG00005052041
 protein coding gene Chr2:88691271-88726771 (-)
CBA/J ENSMUSG00210033515
 protein coding gene Chr2:89457575-89487968 (-)
DBA/2J ENSMUSG00185056117
 protein coding gene Chr2:89181449-89211844 (-)
FVB/NJ ENSMUSG00205052026
 protein coding gene Chr2:88467133-88497520 (-)
JF1/MsJ ENSUMUG00000029812
 protein coding gene Chr2:89002076-89032728 (-)
LP/J ENSMUSG00230039763
 protein coding gene Chr2:90931969-90962362 (-)
NOD/ShiLtJ ENSMUSG00190040749
 protein coding gene Chr2:89260092-89290487 (-)
NZO/HlLtJ ENSMUSG00225051288
 protein coding gene Chr2:98847192-98877572 (-)
PWK/PhJ ENSLUMG00010050495
 protein coding gene Chr2:88978804-89009309 (-)
SPRET/EiJ ENSMSPG00010052071
 protein coding gene Chr2:90946536-90970070 (-)
WSB/EiJ ENSIUOG00005053323
 protein coding gene Chr2:88986174-89016545 (-)



Homology
more
  • Human Ortholog
    CRY2, cryptochrome circadian regulator 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRY2, cryptochrome circadian regulator 2
  • Synonyms
    HCRY2, PHLL2
  • Links
    NCBI Gene ID: 1408
    UniProt: Q49AN0

  • Chr Location
    11p11.2; chr11:45847118-45883248 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    40 phenotypes from multigenic genotypes
    1 images
    167 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit a one-hour longer circadian period under constant darkness, and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    99
  • GO References
    43
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    116
  • cDNA Data
    66
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068742 Ensembl Gene Model | MGI Sequence Detail 30398 C57BL/6J ±  kb
    transcript ENSMUST00000090559 Ensembl | MGI Sequence Detail 3976 Not Applicable  
    polypeptide ENSMUSP00000088047 Ensembl | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 3
      cDNA 67
      Primer pair 3
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139231, MGI:2444176
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 10
      Gene Ontology 43
      Phenotypes 167
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:386199 Weger M, et al., Feeding-regulated glycogen metabolism drives rhythmic liver protein secretion. Nat Metab. 2026 Feb;8(2):327-349
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory