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Wwc2 Gene Detail
Summary
  • Symbol
    Wwc2
  • Name
    WW, C2 and coiled-coil domain containing 2
  • Synonyms
    D8Ertd594e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261872
    NCBI Gene: 52357
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:48279117-48443579 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 26.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4729 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261872
protein coding gene Chr8:48276994-48443959 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033604
protein coding gene Chr8:47032351-47205814 (-)
A/J MGP_AJ_G0033586
protein coding gene Chr8:45183966-45349681 (-)
AKR/J MGP_AKRJ_G0033511
protein coding gene Chr8:46496744-46666857 (-)
BALB/cJ MGP_BALBcJ_G0033583
protein coding gene Chr8:45362626-45526951 (-)
C3H/HeJ MGP_C3HHeJ_G0033292
protein coding gene Chr8:47068942-47238016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034099
protein coding gene Chr8:48827006-49003036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031047
protein coding gene Chr8:41417613-41584407 (-)
CAST/EiJ MGP_CASTEiJ_G0032618
protein coding gene Chr8:46531005-46709050 (-)
CBA/J MGP_CBAJ_G0033271
protein coding gene Chr8:50743755-50923827 (-)
DBA/2J MGP_DBA2J_G0033424
protein coding gene Chr8:44988316-45153876 (-)
FVB/NJ MGP_FVBNJ_G0033365
protein coding gene Chr8:44453617-44622102 (-)
LP/J MGP_LPJ_G0033512
protein coding gene Chr8:47019711-47197657 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033409
protein coding gene Chr8:50777874-50956466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034117
protein coding gene Chr8:46695142-46871131 (-)
PWK/PhJ MGP_PWKPhJ_G0032326
protein coding gene Chr8:44520153-44689910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032162
protein coding gene Chr8:45857075-46028080 (-)
WSB/EiJ MGP_WSBEiJ_G0032734
protein coding gene Chr8:46944879-47115795 (-)



Homology
more
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWC2, WW and C2 domain containing 2
  • Synonyms
    BOMB
  • Links
    NCBI Gene ID: 80014
    neXtProt AC: NX_Q6AWC2
    UniProt: Q6AWC2

  • Chr Location
    4q35.1; chr4:183099257-183320777 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52357 NCBI Gene Model | MGI Sequence Detail 164463 C57BL/6J ±  kb
    transcript NM_133791 RefSeq | MGI Sequence Detail 6548 ZRU/MplStud  
    polypeptide Q6NXJ0 UniProt | EBI | MGI Sequence Detail 1187 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142705, MGI:2142867
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:358155 Dunham TL, et al., WWC2 modulates GABA(A)-receptor-mediated synaptic transmission, revealing class-specific mechanisms of synapse regulation by WWC family proteins. Cell Rep. 2024 Oct 22;43(10):114841

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    11/19/2024
    MGI 6.24
    The Jackson Laboratory