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Pik3c2g Gene Detail
Summary
  • Symbol
    Pik3c2g
  • Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203730
    NCBI Gene: 18705
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:139591070-139915010 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 69.70 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11061 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203730
 protein coding gene Chr6:139564219-139915010 (+)
129S1/SvImJ ENSMUSG00200033349
 protein coding gene Chr6:137198095-137450927 (+)
129S1/SvImJ ENSMUSG00200033277
 protein coding gene Chr6:137112499-137182516 (+)
A/J ENSMUSG00195007551
 protein coding gene Chr6:136090344-136356511 (+)
AKR/J ENSMUSG00220027197
 protein coding gene Chr6:134321275-134587403 (+)
BALB/cJ ENSMUSG00180016641
 protein coding gene Chr6:136183205-136449323 (+)
C3H/HeJ ENSMUSG00175030810
 protein coding gene Chr6:136117992-136384144 (+)
C57BL/6NJ ENSMUSG00215025005
 protein coding gene Chr6:136205210-136275225 (+)
C57BL/6NJ ENSMUSG00215025190
 protein coding gene Chr6:136286171-136556363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029017
 protein coding gene Chr6:137492090-137824457 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210004418
 protein coding gene Chr6:136179339-136446302 (+)
DBA/2J ENSMUSG00185021938
 protein coding gene Chr6:136830800-137096955 (+)
FVB/NJ ENSMUSG00205019973
 protein coding gene Chr6:135251347-135501818 (+)
JF1/MsJ ENSUMUG00000004708
 protein coding gene Chr6:135491174-135757291 (+)
LP/J ENSMUSG00230006482
 protein coding gene Chr6:137993841-138247167 (+)
LP/J ENSMUSG00230006410
 protein coding gene Chr6:137908273-137978262 (+)
NOD/ShiLtJ ENSMUSG00190005867
 protein coding gene Chr6:136668642-136934791 (+)
NZO/HlLtJ ENSMUSG00225007225
 protein coding gene Chr6:140745050-140815075 (+)
NZO/HlLtJ ENSMUSG00225007238
 protein coding gene Chr6:140830655-141084044 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIK3C2G, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
  • Synonyms
    PI3K-C2-gamma, PI3K-C2GAMMA
  • Links
    NCBI Gene ID: 5288
    UniProt: O75747

  • Chr Location
    12p12.3; chr12:18242960-18726817 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PIK3C2G associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allelel exhibit reduced liver glucogen accumulation, hyperlipidemia, adiposity and insulin resistance with age or after consumption of a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    705
  • Tissues
    106
  • cDNA Data
    13
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18705 NCBI Gene Model | MGI Sequence Detail 323941 C57BL/6J ±  kb
    transcript NM_207683 RefSeq | MGI Sequence Detail 6280 ZRU/MplStud  
    polypeptide O70167 UniProt | EBI | MGI Sequence Detail 1506 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012717 phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
      (term hierarchy)
    • EC
      2.7.1.137, 2.7.1.154
    • InterPro Domains
      IPR016024 Armadillo-type fold
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR002420 C2 phosphatidylinositol 3-kinase-type domain
      IPR015433 Phosphatidylinositol 3-/4-kinase
      IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
      IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
      IPR018936 Phosphatidylinositol 3-/4-kinase, conserved site
      IPR037707 Phosphatidylinositol 3-kinase C2-gamma, catalytic domain
      IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
      IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
      IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
      IPR001683 Phox homology
      IPR011009 Protein kinase-like domain superfamily
      IPR036871 PX domain superfamily
      IPR029071 Ubiquitin-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 14
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141760
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 2
    • Earliest
      J:46628 Misawa H, et al., Cloning and characterization of a novel class II phosphoinositide 3-kinase containing C2 domain. Biochem Biophys Res Commun. 1998 Mar 17;244(2):531-9
    • Latest
      J:285468 Keele GR, et al., Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation. PLoS Genet. 2020 Jan;16(1):e1008537
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory