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Zfp638 Gene Detail
Summary
  • Symbol
    Zfp638
  • Name
    zinc finger protein 638
  • Synonyms
    Np220, Zfml
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203484
    NCBI Gene: 18139
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:83844050-83963855 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 36.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1746 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203484
protein coding gene Chr6:83844050-83966532 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030943
protein coding gene Chr6:84909194-85038853 (+)
A/J MGP_AJ_G0030912
protein coding gene Chr6:81674213-81795899 (+)
AKR/J MGP_AKRJ_G0030840
protein coding gene Chr6:84036502-84164622 (+)
BALB/cJ MGP_BALBcJ_G0030922
protein coding gene Chr6:81702535-81824645 (+)
C3H/HeJ MGP_C3HHeJ_G0030788
protein coding gene Chr6:100251431-100374030 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031382
protein coding gene Chr6:87255341-87383761 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028568
protein coding gene Chr6:80040894-80165159 (+)
CAST/EiJ MGP_CASTEiJ_G0030031
protein coding gene Chr6:84061290-84186865 (+)
CBA/J MGP_CBAJ_G0030609
protein coding gene Chr6:90680248-90819084 (+)
DBA/2J MGP_DBA2J_G0030762
protein coding gene Chr6:80986714-81109980 (+)
FVB/NJ MGP_FVBNJ_G0030715
protein coding gene Chr6:80199441-80322978 (+)
LP/J MGP_LPJ_G0030841
protein coding gene Chr6:84912329-85038066 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030751
protein coding gene Chr6:94950628-95099386 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031406
protein coding gene Chr6:83863600-83989540 (+)
PWK/PhJ MGP_PWKPhJ_G0029746
protein coding gene Chr6:79899978-80024333 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029574
protein coding gene Chr6:82690940-82815199 (+)
WSB/EiJ MGP_WSBEiJ_G0030112
protein coding gene Chr6:84287797-84412774 (+)



Homology
more
  • Human Ortholog
    ZNF638, zinc finger protein 638
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNF638, zinc finger protein 638
  • Synonyms
    NP220, ZFML, Zfp638
  • Links
    NCBI Gene ID: 27332
    neXtProt AC: NX_Q14966
    UniProt: Q14966

  • Chr Location
    2p13.2; chr2:71276561-71435069 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18139 NCBI Gene Model | MGI Sequence Detail 119806 C57BL/6J ±  kb
transcript NM_001406074 RefSeq | MGI Sequence Detail 6444 C57BL/6  
polypeptide Q61464 UniProt | EBI | MGI Sequence Detail 1960 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000018045 zinc finger protein 638
  • InterPro Domains
    IPR026811 Cip1-interacting zinc finger protein
    IPR000690 Matrin/U1-C, C2H2-type zinc finger
    IPR003604 Matrin/U1-C-like, C2H2-type zinc finger
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR036236 Zinc finger C2H2 superfamily
    IPR013087 Zinc finger C2H2-type
    IPR022755 Zinc finger, double-stranded RNA binding
    IPR033096 Zinc finger protein 638, RNA recognition motif 1/2
  • GlyGen
    Q61464 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 169
    cDNA 167
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2141390
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:33575 Matsushima Y, et al., A family of novel DNA-binding nuclear proteins having polypyrimidine tract-binding motif and arginine/serine-rich motif. Biochem Biophys Res Commun. 1996 Jun 14;223(2):427-33
  • Latest
    J:346397 Meng M, et al., Zinc finger protein ZNF638 regulates triglyceride metabolism via ANGPTL8 in an estrogen dependent manner. Metabolism. 2024 Jan 9;152:155784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory