About   Help   FAQ
Map3k19 Gene Detail
Summary
  • Symbol
    Map3k19
  • Name
    mitogen-activated protein kinase kinase kinase 19
  • Synonyms
    Ysk4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1203481
    NCBI Gene: 22625
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:127742528-127782768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 55.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1226 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1203481
 protein coding gene Chr1:127741217-127782768 (-)
129S1/SvImJ ENSMUSG00200007802
 protein coding gene Chr1:125307765-125348017 (-)
A/J ENSMUSG00195043440
 protein coding gene Chr1:124392084-124432338 (-)
AKR/J ENSMUSG00220047189
 protein coding gene Chr1:124244187-124284450 (-)
BALB/cJ ENSMUSG00180035914
 protein coding gene Chr1:124961991-125002253 (-)
C3H/HeJ ENSMUSG00175039979
 protein coding gene Chr1:124660764-124701013 (-)
C57BL/6NJ ENSMUSG00215042509
 protein coding gene Chr1:124662958-124703207 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014540
 protein coding gene Chr1:119513340-119554321 (-)
CAST/EiJ ENSTCUG00005028763
 protein coding gene Chr1:123593960-123633802 (-)
CBA/J ENSMUSG00210026127
 protein coding gene Chr1:124530327-124570565 (-)
DBA/2J ENSMUSG00185001857
 protein coding gene Chr1:128906158-128946416 (-)
FVB/NJ ENSMUSG00205033464
 protein coding gene Chr1:123866431-123906683 (-)
JF1/MsJ ENSUMUG00000002277
 protein coding gene Chr1:128043056-128083500 (-)
LP/J ENSMUSG00230000949
 protein coding gene Chr1:128486143-128526396 (-)
NOD/ShiLtJ ENSMUSG00190029459
 protein coding gene Chr1:124547767-124588008 (-)
NZO/HlLtJ ENSMUSG00225004573
 protein coding gene Chr1:132209674-132249923 (-)
PWK/PhJ ENSLUMG00010022565
 protein coding gene Chr1:123670903-123711015 (-)
SPRET/EiJ ENSMSPG00010037977
 protein coding gene Chr1:126413242-126452565 (-)
WSB/EiJ ENSIUOG00005046917
 protein coding gene Chr1:124260676-124300572 (-)



Homology
more
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K19, mitogen-activated protein kinase kinase kinase 19
  • Synonyms
    RCK, YSK4
  • Links
    NCBI Gene ID: 80122
    UniProt: Q56UN5

  • Chr Location
    2q21.3; chr2:134964485-135047468 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Radiation induced
    1
  • Genomic Mutations
    3 involving Map3k19
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    57 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    659
  • Tissues
    9
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000051590 Ensembl Gene Model | MGI Sequence Detail 40241 C57BL/6J ±  kb
transcript ENSMUST00000208183 Ensembl | MGI Sequence Detail 5345 Not Applicable  
polypeptide ENSMUSP00000146463 Ensembl | MGI Sequence Detail 1515 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory