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Ints6 Gene Detail
Summary
  • Symbol
    Ints6
  • Name
    integrator complex subunit 6
  • Synonyms
    2900075H24Rik, Ddx26, DICE1, Notch2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202397
    NCBI Gene: 18130
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:62913779-62998618 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.23 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1600 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202397
 protein coding gene Chr14:62913774-62998618 (-)
129S1/SvImJ ENSMUSG00200030187
 protein coding gene Chr14:51514067-51598268 (-)
A/J ENSMUSG00195029698
 protein coding gene Chr14:51685756-51770586 (-)
AKR/J ENSMUSG00220028112
 protein coding gene Chr14:51033113-51117983 (-)
BALB/cJ ENSMUSG00180051127
 protein coding gene Chr14:51307673-51392505 (-)
C3H/HeJ ENSMUSG00175035310
 protein coding gene Chr14:53049887-53134081 (-)
C57BL/6NJ ENSMUSG00215045232
 protein coding gene Chr14:51241021-51325804 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019393
 protein coding gene Chr14:53812725-53898780 (-)
CAST/EiJ ENSTCUG00005038893
 protein coding gene Chr14:52973519-53058240 (-)
CBA/J ENSMUSG00210037384
 protein coding gene Chr14:51673652-51758493 (-)
DBA/2J ENSMUSG00185030809
 protein coding gene Chr14:56847685-56931879 (-)
FVB/NJ ENSMUSG00205023628
 protein coding gene Chr14:51192744-51275998 (-)
JF1/MsJ ENSUMUG00000040982
 protein coding gene Chr14:68038145-68122572 (-)
LP/J ENSMUSG00230033362
 protein coding gene Chr14:68877268-68961467 (-)
NOD/ShiLtJ ENSMUSG00190031065
 protein coding gene Chr14:51470033-51553238 (-)
NZO/HlLtJ ENSMUSG00225044744
 protein coding gene Chr14:59210538-59295386 (-)
PWK/PhJ ENSLUMG00010045828
 protein coding gene Chr14:50924317-51008731 (-)
SPRET/EiJ ENSMSPG00010030058
 protein coding gene Chr14:54404609-54479873 (-)
WSB/EiJ ENSIUOG00005037605
 protein coding gene Chr14:50921263-51006000 (-)



Homology
more
  • Human Ortholog
    INTS6, integrator complex subunit 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INTS6, integrator complex subunit 6
  • Synonyms
    DBI-1, DDX26, DDX26A, DICE1, HDB, INT6, MRD78, Notchl2
  • Links
    NCBI Gene ID: 26512
    UniProt: Q9UL03

  • Chr Location
    13q14.3; chr13:51334405-51454264 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    7
  • cDNA Data
    14
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035161 Ensembl Gene Model | MGI Sequence Detail 84840 C57BL/6J ±  kb
transcript ENSMUST00000053959 Ensembl | MGI Sequence Detail 4993 Not Applicable  
polypeptide ENSMUSP00000086788 Ensembl | MGI Sequence Detail 883 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009075 integrator complex subunit 6
    (term hierarchy)
  • InterPro Domains
    IPR051113 Integrator complex subunit 6
    IPR057413 Integrator complex subunit 6-like, beta-barrel domain
    IPR029307 INTS6/SAGE1/DDX26B/CT45, C-terminal
    IPR036465 von Willebrand factor A-like domain superfamily
    IPR002035 von Willebrand factor, type A
  • GlyGen
    Q6PCM2 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1920288, MGI:2145666
References
more
  • Summaries
    All 48
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:45989 Hoff HB 3rd, et al., DBI-1, a novel gene related to the notch family, modulates mitogenic response to insulin-like growth factor 1. Exp Cell Res. 1998 Feb 1;238(2):359-70
  • Latest
    J:379194 D'Amico S, et al., Loss of Snhg5 disrupts cell-cycle regulation without altering cystogenesis in a mouse model of polycystic kidney disease. Sci Rep. 2026 Jan 8;16(1):4869
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory