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Hnrnph2 Gene Detail
Summary
  • Symbol
    Hnrnph2
  • Name
    heterogeneous nuclear ribonucleoprotein H2
  • Synonyms
    Ftp3, Hnrph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201779
    NCBI Gene: 56258
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:133501928-133507809 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 56.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201779
 protein coding gene ChrX:133501928-133507809 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027044
 protein coding gene Chr3:954694-956796 (+)
A/J MGP_AJ_G0027008
 protein coding gene Chr3:1315638-1317780 (+)
AKR/J MGP_AKRJ_G0035975
 protein coding gene ChrX:135417192-135422972 (+)
BALB/cJ MGP_BALBcJ_G0027017
 protein coding gene Chr3:1034652-1036944 (+)
C3H/HeJ MGP_C3HHeJ_G0035749
 protein coding gene ChrX:131865727-131871535 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027462
 protein coding gene Chr3:1357838-1359946 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033396
 protein coding gene ChrX:123391129-123396973 (+)
CAST/EiJ MGP_CASTEiJ_G0026216
 protein coding gene Chr3:1316051-1318045 (-)
CBA/J MGP_CBAJ_G0026736
 protein coding gene Chr3:1031106-1032202 (+)
DBA/2J MGP_DBA2J_G0035881
 protein coding gene ChrX:130516805-130523253 (+)
FVB/NJ MGP_FVBNJ_G0035822
 protein coding gene ChrX:129839785-129846384 (+)
LP/J MGP_LPJ_G0035974
 protein coding gene ChrX:132667425-132673628 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035851
 protein coding gene ChrX:147097824-147103791 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036598
 protein coding gene ChrX:131218306-131223907 (+)
PWK/PhJ MGP_PWKPhJ_G0034729
 protein coding gene ChrX:109678599-109687166 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034560
 protein coding gene ChrX:113377083-113382886 (+)
WSB/EiJ MGP_WSBEiJ_G0035175
 protein coding gene ChrX:129583186-129588107 (+)



Homology
more
  • Human Ortholog
    HNRNPH2, heterogeneous nuclear ribonucleoprotein H2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPH2, heterogeneous nuclear ribonucleoprotein H2
  • Synonyms
    FTP3, hnRNPH', HNRPH', HNRPH2, MRXSB, NRPH2
  • Links
    NCBI Gene ID: 3188
    neXtProt AC: NX_P55795
    UniProt: P55795

  • Chr Location
    Xq22.1; chrX:101408222-101414133 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hnrnph2 mouse models; 1 with human HNRNPH2 associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    26
  • cDNA Data
    142
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56258 NCBI Gene Model | MGI Sequence Detail 5882 C57BL/6J ±  kb
    transcript NM_019868 RefSeq | MGI Sequence Detail 2489 ZRU/MplStud  
    polypeptide P70333 UniProt | EBI | MGI Sequence Detail 449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 145
      Genomic 1
      cDNA 142
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:39674 Oeltjen JC, et al., Large-scale comparative sequence analysis of the human and murine Bruton's tyrosine kinase loci reveals conserved regulatory domains. Genome Res. 1997 Apr;7(4):315-29
    • Latest
      J:338313 Korff A, et al., A murine model of hnRNPH2-related neurodevelopmental disorder reveals a mechanism for genetic compensation by Hnrnph1. J Clin Invest. 2023 Jul 17;133(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory