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Ctbp2 Gene Detail
Summary
  • Symbol
    Ctbp2
  • Name
    C-terminal binding protein 2
  • Synonyms
    D7Ertd45e, Gtrgeo6, Ribeye
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201686
    NCBI Gene: 13017
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132589292-132726083 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.32 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3685 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201686
 protein coding gene Chr7:132588727-132726083 (-)
129S1/SvImJ ENSMUSG00200023400
 protein coding gene Chr7:119118753-119162942 (-)
A/J ENSMUSG00195039108
 protein coding gene Chr7:123589400-123633593 (-)
AKR/J ENSMUSG00220016018
 protein coding gene Chr7:117051572-117095759 (-)
BALB/cJ ENSMUSG00180011298
 protein coding gene Chr7:120295620-120339809 (-)
C3H/HeJ ENSMUSG00175017360
 protein coding gene Chr7:121022234-121064009 (-)
C3H/HeJ ENSMUSGG00175054654
 protein coding gene Chr7:121065944-121066114 (-)
C57BL/6NJ ENSMUSG00215009182
 protein coding gene Chr7:120299559-120343752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030584
 protein coding gene Chr7:135189310-135326948 (-)
CAST/EiJ ENSTCUG00005046534
 protein coding gene Chr7:123607378-123651620 (-)
CBA/J ENSMUSG00210023120
 protein coding gene Chr7:120789161-120833350 (-)
DBA/2J ENSMUSG00185022335
 protein coding gene Chr7:125100110-125144303 (-)
FVB/NJ ENSMUSG00205027106
 protein coding gene Chr7:120734536-120778729 (-)
JF1/MsJ ENSUMUG00000040172
 protein coding gene Chr7:130107649-130151767 (-)
LP/J ENSMUSG00230052306
 protein coding gene Chr7:131229606-131273776 (-)
NOD/ShiLtJ ENSMUSG00190014250
 protein coding gene Chr7:120923326-120967511 (-)
NZO/HlLtJ ENSMUSG00225012200
 protein coding gene Chr7:129457523-129501715 (-)
PWK/PhJ ENSLUMG00010036039
 protein coding gene Chr7:119299489-119343339 (-)
SPRET/EiJ ENSMSPG00010011620
 protein coding gene Chr7:120604760-120643022 (-)
WSB/EiJ ENSIUOG00005027340
 protein coding gene Chr7:121613940-121658087 (-)



Homology
more
  • Human Ortholog
    CTBP2, C-terminal binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTBP2, C-terminal binding protein 2
  • Links
    NCBI Gene ID: 1488
    UniProt: P56545

  • Chr Location
    10q26.13; chr10:124981657-125163006 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene-trapped allele die by E10 exhibiting a small size, axial truncations, a thin neural epithelium, a dilated pericardium, delayed fore- and midbrain development, and defects in heart morphogenesis, placental development and extraembryonic vascularization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    868
  • Tissues
    86
  • cDNA Data
    27
  • Literature Summary
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030970 Ensembl Gene Model | MGI Sequence Detail 136792 C57BL/6J ±  kb
    transcript ENSMUST00000169570 Ensembl | MGI Sequence Detail 3604 Not Applicable  
    polypeptide ENSMUSP00000130294 Ensembl | MGI Sequence Detail 988 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • Protein Ontology
      PR:000005995 C-terminal-binding protein 2
      (term hierarchy)
    • InterPro Domains
      IPR051638 C-terminal-binding dehydrogenase
      IPR043322 C-terminal binding protein
      IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
      IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
      IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      P56546 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 28
      Primer pair 5
      Antibodies 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1098619, MGI:2141805, MGI:894664
    References
    more
    • Summaries
      All 193
      Developmental Gene Expression 64
      Gene Ontology 27
      Phenotypes 35
    • Earliest
      J:40477 Baker RK, et al., In vitro preselection of gene-trapped embryonic stem cell clones for characterizing novel developmentally regulated genes in the mouse. Dev Biol. 1997 May 15;185(2):201-14
    • Latest
      J:391692 Chen W, et al., Obesity Disrupts CtBP2-Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry. FASEB J. 2026 Aug 15;40(15):e72172
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory