About   Help   FAQ
Anxa8 Gene Detail
Summary
  • Symbol
    Anxa8
  • Name
    annexin A8
  • Synonyms
    Anx8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201374
    NCBI Gene: 11752
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33807938-33822528 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201374
protein coding gene Chr14:33807936-33822528 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021166
protein coding gene Chr14:27420918-27435428 (+)
A/J MGP_AJ_G0021114
protein coding gene Chr14:26360832-26375422 (+)
AKR/J MGP_AKRJ_G0021091
protein coding gene Chr14:27534140-27548730 (+)
BALB/cJ MGP_BALBcJ_G0021118
protein coding gene Chr14:26545681-26560283 (+)
C3H/HeJ MGP_C3HHeJ_G0020901
protein coding gene Chr14:27451652-27466183 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021550
protein coding gene Chr14:28480238-28494816 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019112
protein coding gene Chr14:26396713-26411146 (+)
CAST/EiJ MGP_CASTEiJ_G0020426
protein coding gene Chr14:27270846-27285359 (+)
CBA/J MGP_CBAJ_G0020868
protein coding gene Chr14:29503356-29517886 (+)
DBA/2J MGP_DBA2J_G0020990
protein coding gene Chr14:26394577-26409008 (+)
FVB/NJ MGP_FVBNJ_G0020974
protein coding gene Chr14:26360517-26375120 (+)
LP/J MGP_LPJ_G0021059
protein coding gene Chr14:27755025-27769569 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021000
protein coding gene Chr14:28660678-28675264 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021583
protein coding gene Chr14:27366702-27381414 (+)
PWK/PhJ MGP_PWKPhJ_G0020174
protein coding gene Chr14:25888819-25903255 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019998
protein coding gene Chr14:26966286-26980278 (+)
WSB/EiJ MGP_WSBEiJ_G0020481
protein coding gene Chr14:27421473-27436058 (+)



Homology
more
  • Human Ortholog
    ANXA8, annexin A8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA8, annexin A8
  • Synonyms
    ANX8, CH17-360D5.2
  • Links
    NCBI Gene ID: 653145
    neXtProt AC: NX_P13928
    UniProt: P13928

  • Chr Location
    10q11.22; chr10:47460162-47991796 (-)  GRCh38

  • Human Ortholog
    ANXA8L1, annexin A8 like 1
  • Synonyms
    ANXA8, ANXA8L2, bA145E20.2, VAC-beta
  • Links
    NCBI Gene ID: 728113
    neXtProt AC: NX_P13928, NX_Q5VT79
    UniProt: Q5VT79

  • Chr Location
    10q11.22; chr10:46375627-46391784 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in all cells exhibit impaired leukocyte rolling flux and adhesion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021950 Ensembl Gene Model | MGI Sequence Detail 14591 C57BL/6J ±  kb
transcript ENSMUST00000022519 Ensembl | MGI Sequence Detail 1880 Not Applicable  
polypeptide ENSMUSP00000022519 Ensembl | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 56
    cDNA 52
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145662
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:45414 Fernandez MP, et al., The genetic origin of mouse annexin VIII. Mamm Genome. 1998 Jan;9(1):8-14
  • Latest
    J:319854 Youlten SE, et al., Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Nat Commun. 2021 May 5;12(1):2444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory