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Adgre4 Gene Detail
Summary
  • Symbol
    Adgre4
  • Name
    adhesion G protein-coupled receptor E4
  • Synonyms
    D17Ertd479e, EGF-TM7, Emr4, FIRE, Gpr127
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196464
    NCBI Gene: 52614
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56056984-56160662 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 28.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2010 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196464
 protein coding gene Chr17:56056984-56160662 (+)
129S1/SvImJ ENSMUSG00200016341
 protein coding gene Chr17:51331729-51435412 (+)
A/J ENSMUSG00195006754
 protein coding gene Chr17:52719320-52822997 (+)
AKR/J ENSMUSG00220012501
 protein coding gene Chr17:51768748-51872425 (+)
BALB/cJ ENSMUSG00180005974
 protein coding gene Chr17:52476958-52580612 (+)
C3H/HeJ ENSMUSG00175006736
 protein coding gene Chr17:51793059-51896719 (+)
C57BL/6NJ ENSMUSG00215007082
 protein coding gene Chr17:51407138-51510820 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021750
 protein coding gene Chr17:52127709-52447499 (+)
CAST/EiJ ENSTCUG00005018065
 protein coding gene Chr17:52531587-52630163 (+)
CBA/J ENSMUSG00210026114
 protein coding gene Chr17:51560098-51663760 (+)
DBA/2J ENSMUSG00185008965
 protein coding gene Chr17:54429960-54533637 (+)
FVB/NJ ENSMUSG00205006692
 protein coding gene Chr17:52114349-52211085 (+)
JF1/MsJ ENSUMUG00000019726
 protein coding gene Chr17:54099823-54216055 (+)
LP/J ENSMUSG00230024129
 protein coding gene Chr17:55409179-55512854 (+)
NOD/ShiLtJ ENSMUSG00190009499
 protein coding gene Chr17:51562565-51666240 (+)
NZO/HlLtJ ENSMUSG00225041707
 protein coding gene Chr17:57693146-57796843 (+)
PWK/PhJ ENSLUMG00010008982
 protein coding gene Chr17:51368350-51477128 (+)
SPRET/EiJ ENSMSPG00010005592
 protein coding gene Chr17:51679122-51778760 (+)
WSB/EiJ ENSIUOG00005023524
 protein coding gene Chr17:52464021-52567741 (+)



Homology
more
  • Human Ortholog
    ADGRE4P, adhesion G protein-coupled receptor E4, pseudogene
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRE4P, adhesion G protein-coupled receptor E4, pseudogene
  • Synonyms
    EMR4, EMR4P, FIRE, GPR127, PGR16
  • Links
    NCBI Gene ID: 326342

  • Chr Location
    19p13.2; chr19:6950758-6997851 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    7
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 52614 NCBI Gene Model | MGI Sequence Detail 103679 C57BL/6J ±  kb
transcript NM_139138 RefSeq | MGI Sequence Detail 3491 ZRU/MplStud  
polypeptide Q91ZE5 UniProt | EBI | MGI Sequence Detail 689 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:44944 Hsu DK, et al., Differential control of murine aldose reductase and fibroblast growth factor (FGF)-regulated-1 gene expression in NIH 3T3 cells by FGF-1 treatment and hyperosmotic stress. Biochem J. 1997 Dec 1;328(Pt 2):593-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory