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Tmem254 Gene Detail
Summary
  • Symbol
    Tmem254
  • Name
    transmembrane protein 254
  • Synonyms
    0610008K04Rik, 0610010A22Rik, D14Ertd449e, Gm10395, Gm9746, Tmem254a, Tmem254b, Tmem254c
Location &
Maps
more
  • Sequence Map
    Chr14:25923724-25928096 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 15.49 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196450
 protein coding gene Chr14:25923722-25928096 (-)
129S1/SvImJ ENSMUSG00200013978
 protein coding gene Chr14:17728077-17732449 (-)
A/J ENSMUSG00195021967
 protein coding gene Chr14:18796011-18800383 (-)
AKR/J ENSMUSG00220026219
 protein coding gene Chr14:17895636-17900008 (-)
BALB/cJ ENSMUSG00180033661
 protein coding gene Chr14:17887883-17892255 (-)
C3H/HeJ ENSMUSG00175020471
 protein coding gene Chr14:17955491-17959863 (-)
C57BL/6NJ ENSMUSG00215029388
 protein coding gene Chr14:18203737-18208109 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210025560
 protein coding gene Chr14:18190264-18194636 (-)
DBA/2J ENSMUSG00185035348
 protein coding gene Chr14:22484989-22489361 (-)
FVB/NJ ENSMUSG00205033064
 protein coding gene Chr14:18017246-18021618 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230036103
 protein coding gene Chr14:29757078-29761450 (-)
NOD/ShiLtJ ENSMUSG00190025165
 protein coding gene Chr14:18201118-18205490 (-)
NZO/HlLtJ ENSMUSG00225036755
 protein coding gene Chr14:23990485-23994857 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TMEM254, transmembrane protein 254
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM254, transmembrane protein 254
  • Synonyms
    bA369J21.6, C10orf57
  • Links
    NCBI Gene ID: 80195
    UniProt: Q8TBM7

  • Chr Location
    10q22.3; chr10:80078646-80092557 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    26
  • cDNA Data
    15
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000072676 Ensembl Gene Model | MGI Sequence Detail 4373 C57BL/6J ±  kb
    transcript ENSMUST00000100811 Ensembl | MGI Sequence Detail 1108 Not Applicable  
    polypeptide ENSMUSP00000098374 Ensembl | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 15
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913289, MGI:1915584, MGI:2145586, MGI:3710397, MGI:3711260, MGI:6729948
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Gene Ontology 1
      Phenotypes 5
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory