About   Help   FAQ
Ildr2 Gene Detail
Summary
  • Symbol
    Ildr2
  • Name
    immunoglobulin-like domain containing receptor 2
  • Synonyms
    2810478N18Rik, 3110063L10Rik, D1Ertd471e, Dbsm1, ENSMUSG00000040612, OTTMUSG00000021748
Location &
Maps
more
  • Sequence Map
    Chr1:166081708-166144392 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1758 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196370
 protein coding gene Chr1:166081630-166144405 (+)
129S1/SvImJ ENSMUSG00200042257
 protein coding gene Chr1:163583474-163646170 (+)
A/J ENSMUSG00195047316
 protein coding gene Chr1:162892120-162954825 (+)
AKR/J ENSMUSG00220012976
 protein coding gene Chr1:162680651-162743351 (+)
BALB/cJ ENSMUSG00180038928
 protein coding gene Chr1:163137460-163200161 (+)
C3H/HeJ ENSMUSG00175038295
 protein coding gene Chr1:163233220-163295918 (+)
C57BL/6NJ ENSMUSG00215036080
 protein coding gene Chr1:163019143-163081843 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014815
 protein coding gene Chr1:156649012-156711142 (+)
CAST/EiJ ENSTCUG00005019884
 protein coding gene Chr1:161641170-161704888 (+)
CBA/J ENSMUSG00210039088
 protein coding gene Chr1:163107681-163170381 (+)
DBA/2J ENSMUSG00185010482
 protein coding gene Chr1:167353030-167415753 (+)
FVB/NJ ENSMUSG00205009825
 protein coding gene Chr1:162151832-162214404 (+)
JF1/MsJ ENSUMUG00000004851
 protein coding gene Chr1:166504147-166574073 (+)
LP/J ENSMUSG00230019199
 protein coding gene Chr1:166972504-167035200 (+)
NOD/ShiLtJ ENSMUSG00190025473
 protein coding gene Chr1:162942681-163005668 (+)
NZO/HlLtJ ENSMUSG00225002362
 protein coding gene Chr1:170558323-170621020 (+)
PWK/PhJ ENSLUMG00010038250
 protein coding gene Chr1:161874672-161937317 (+)
SPRET/EiJ ENSMSPG00010046782
 protein coding gene Chr1:165365743-165423837 (+)
WSB/EiJ ENSIUOG00005013895
 protein coding gene Chr1:162408686-162471201 (+)



Homology
more
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Synonyms
    C1orf32, dJ782G3.1
  • Links
    NCBI Gene ID: 387597
    UniProt: Q71H61

  • Chr Location
    1q24.1; chr1:166895696-166975540 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced stop mutation at threonine-87 display a reduced pancreatic beta-cell replication rate, decreased beta-cell mass, reduced insulin/glucose ratio in blood, impaired glucose tolerance, and persistent mild hypoinsulinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    5
  • cDNA Data
    49
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040612 Ensembl Gene Model | MGI Sequence Detail 62685 C57BL/6J ±  kb
    transcript ENSMUST00000111416 Ensembl | MGI Sequence Detail 8251 Not Applicable  
    polypeptide ENSMUSP00000107047 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      cDNA 49
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920058, MGI:1920459, MGI:2138362, MGI:3641863, MGI:3814221
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
    • Latest
      J:359192 Siegerist F, et al., The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights. iScience. 2024 Dec 20;27(12):111329
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory