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Agpat5 Gene Detail
Summary
  • Symbol
    Agpat5
  • Name
    1-acylglycerol-3-phosphate O-acyltransferase 5
  • Synonyms
    1110013A05Rik, D8Ertd319e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196345
    NCBI Gene: 52123
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:18896295-18934429 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 10.30 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196345
protein coding gene Chr8:18896293-18941377 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033405
protein coding gene Chr8:16319946-16365777 (+)
A/J MGP_AJ_G0033386
protein coding gene Chr8:15762961-15800112 (+)
AKR/J MGP_AKRJ_G0033316
protein coding gene Chr8:16213973-16263135 (+)
BALB/cJ MGP_BALBcJ_G0033386
protein coding gene Chr8:15871200-15916643 (+)
C3H/HeJ MGP_C3HHeJ_G0033099
protein coding gene Chr8:16409321-16455605 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033898
protein coding gene Chr8:16852718-16899191 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030864
protein coding gene Chr8:15065040-15107575 (+)
CAST/EiJ MGP_CASTEiJ_G0032421
protein coding gene Chr8:16262818-16309622 (+)
CBA/J MGP_CBAJ_G0033072
protein coding gene Chr8:17579217-17617831 (+)
DBA/2J MGP_DBA2J_G0033226
protein coding gene Chr8:15722860-15768219 (+)
FVB/NJ MGP_FVBNJ_G0033174
protein coding gene Chr8:15717290-15763643 (+)
LP/J MGP_LPJ_G0033319
protein coding gene Chr8:16348894-16395132 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033211
protein coding gene Chr8:17738876-17785163 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033915
protein coding gene Chr8:16237732-16282813 (+)
PWK/PhJ MGP_PWKPhJ_G0032134
protein coding gene Chr8:15732310-15778357 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031975
protein coding gene Chr8:16159170-16203664 (+)
WSB/EiJ MGP_WSBEiJ_G0032537
protein coding gene Chr8:16321501-16367686 (+)



Homology
more
  • Human Ortholog
    AGPAT5, 1-acylglycerol-3-phosphate O-acyltransferase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGPAT5, 1-acylglycerol-3-phosphate O-acyltransferase 5
  • Synonyms
    1AGPAT5, LPAATE, LPLAT5
  • Links
    NCBI Gene ID: 55326
    neXtProt AC: NX_Q9NUQ2
    UniProt: Q9NUQ2

  • Chr Location
    8p23.1; chr8:6708642-6761503 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display moderate fatty changes in the liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52123 NCBI Gene Model | MGI Sequence Detail 38135 C57BL/6J ±  kb
    transcript NM_026792 RefSeq | MGI Sequence Detail 3829 ZRU/MplStud  
    polypeptide Q9D1E8 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915880
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 4
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:330249 Strembitska A, et al., Lipid biosynthesis enzyme Agpat5 in AgRP-neurons is required for insulin-induced hypoglycemia sensing and glucagon secretion. Nat Commun. 2022 Sep 30;13(1):5761

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    02/27/2024
    MGI 6.23
    The Jackson Laboratory