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Tcaim Gene Detail
Summary
  • Symbol
    Tcaim
  • Name
    T cell activation inhibitor, mitochondrial
  • Synonyms
    D9Ertd402e, LOC382117
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196217
    NCBI Gene: 382117
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:122634604-122665399 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 73.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196217
 protein coding gene Chr9:122634586-122665399 (+)
129S1/SvImJ ENSMUSG00200026976
 protein coding gene Chr9:119762236-119793029 (+)
A/J ENSMUSG00195024839
 protein coding gene Chr9:118901815-118932623 (+)
AKR/J ENSMUSG00220018051
 protein coding gene Chr9:119373777-119404580 (+)
BALB/cJ ENSMUSG00180024801
 protein coding gene Chr9:119441663-119472470 (+)
C3H/HeJ ENSMUSG00175017529
 protein coding gene Chr9:119678004-119708810 (+)
C57BL/6NJ ENSMUSG00215016543
 protein coding gene Chr9:119597347-119628145 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032844
 protein coding gene Chr9:118121563-118158450 (+)
CAST/EiJ ENSTCUG00005016798
 protein coding gene Chr9:119264489-119295503 (+)
CBA/J ENSMUSG00210034449
 protein coding gene Chr9:119401254-119432082 (+)
DBA/2J ENSMUSG00185014377
 protein coding gene Chr9:119736895-119767725 (+)
FVB/NJ ENSMUSG00205021099
 protein coding gene Chr9:119568394-119599196 (+)
JF1/MsJ ENSUMUG00000042748
 protein coding gene Chr9:119534168-119565340 (+)
LP/J ENSMUSG00230032897
 protein coding gene Chr9:119902392-119933183 (+)
NOD/ShiLtJ ENSMUSG00190014071
 protein coding gene Chr9:119344896-119375694 (+)
NZO/HlLtJ ENSMUSG00225023333
 protein coding gene Chr9:120162700-120193499 (+)
PWK/PhJ ENSLUMG00010031090
 protein coding gene Chr9:119423195-119454369 (+)
SPRET/EiJ ENSMSPG00010019636
 protein coding gene Chr9:121132670-121166955 (+)
WSB/EiJ ENSIUOG00005020130
 protein coding gene Chr9:118768737-118799500 (+)



Homology
more
  • Human Ortholog
    TCAIM, T cell activation inhibitor, mitochondrial
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCAIM, T cell activation inhibitor, mitochondrial
  • Synonyms
    C3orf23, TOAG-1, TOAG1
  • Links
    NCBI Gene ID: 285343
    UniProt: Q8N3R3

  • Chr Location
    3p21.31; chr3:44338119-44409451 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    36
  • cDNA Data
    31
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046603 Ensembl Gene Model | MGI Sequence Detail 30796 C57BL/6J ±  kb
    transcript ENSMUST00000052740 Ensembl | MGI Sequence Detail 3049 Not Applicable  
    polypeptide ENSMUSP00000049759 Ensembl | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000059930 T-cell activation inhibitor, mitochondrial
      (term hierarchy)
    • InterPro Domains
      IPR028031 Domain of unknown function DUF4460
      IPR027989 Domain of unknown function DUF4461
      IPR027986 T-cell activation inhibitor, mitochondrial
    • GlyGen
      Q66JZ4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2685975
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:385712 Jiahui W, et al., The mitochondrial DNAJC co-chaperone TCAIM reduces alpha-ketoglutarate dehydrogenase protein levels to regulate metabolism. Mol Cell. 2025 Feb 6;85(3):638-651.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory