Cd70 MGI Mouse Gene Detail - MGI:1195273

Symbol

Cd70
Name

CD70 antigen
Synonyms

CD27LG, Ki-24 antigen, Tnfsf7

Feature Type

protein coding gene
IDs

MGI:1195273
NCBI Gene: 21948
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:57452997-57456777 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.69 cM, cytoband C-D
Mapping Data

4 experiments

SNPs within 2kb

166 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195273	protein coding gene	Chr17:57452997-57456777 (-)
129S1/SvImJ	ENSMUSG00200016100	protein coding gene	Chr17:52728800-52732580 (-)
A/J	ENSMUSG00195006571	protein coding gene	Chr17:54117007-54120787 (-)
AKR/J	ENSMUSG00220012588	protein coding gene	Chr17:53166356-53170136 (-)
BALB/cJ	ENSMUSG00180005900	protein coding gene	Chr17:53874654-53878434 (-)
C3H/HeJ	ENSMUSG00175007191	protein coding gene	Chr17:53190623-53194403 (-)
C57BL/6NJ	ENSMUSG00215006113	protein coding gene	Chr17:52804231-52808011 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021808	protein coding gene	Chr17:53746249-53750203 (-)
CAST/EiJ	ENSTCUG00005017838	protein coding gene	Chr17:53921751-53925518 (-)
CBA/J	ENSMUSG00210026107	protein coding gene	Chr17:52957678-52961458 (-)
DBA/2J	ENSMUSG00185008488	protein coding gene	Chr17:55827515-55831295 (-)
FVB/NJ	ENSMUSG00205006382	protein coding gene	Chr17:53505039-53508820 (-)
JF1/MsJ	ENSUMUG00000015645	protein coding gene	Chr17:55513141-55516922 (-)
LP/J	ENSMUSG00230028609	protein coding gene	Chr17:56806136-56809916 (-)
NOD/ShiLtJ	ENSMUSG00190010102	protein coding gene	Chr17:52959679-52963459 (-)
NZO/HlLtJ	ENSMUSG00225042100	protein coding gene	Chr17:59090130-59093910 (-)
PWK/PhJ	ENSLUMG00010008628	protein coding gene	Chr17:52765658-52769440 (-)
SPRET/EiJ	ENSMSPG00010005335	protein coding gene	Chr17:53087157-53091033 (-)
WSB/EiJ	ENSIUOG00005022004	protein coding gene	Chr17:53865968-53869749 (-)

Human Ortholog

CD70, CD70 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD70, CD70 molecule
Synonyms

CD27-L, CD27L, CD27LG, LPFS3, TNFSF7, TNLG8A
Links

HGNC:11937

NCBI Gene ID: 970

UniProt: P32970
Chr Location

19p13.3; chr19:6581648-6604103 (-) GRCh38

MGI Vertebrate Homology

Cd70 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD70
Gene Tree

Cd70

Diseases

1 with human CD70 associations

				Human Disease	Mouse Models
				lymphoproliferative syndrome IDs lymphoproliferative syndrome DOID:0060704 OMIM:PS308240 ORDO:538963

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Targeted

4
Transgenic

3
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Expansion of CD8+ cells after viral expansion is significantly less in mice with a homozygous deletion than in controls. However, the restimulation response is comparable to controls.

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All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

657
Tissues

9
cDNA Data

7
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS28927.1

Ensembl

ENSMUSG00000019489 (Evidence)
NCBI Gene

21948

			Length	Strain/Species	Flank
genomic	21948	NCBI Gene Model \| MGI Sequence Detail	3781	C57BL/6J	± kb
transcript	NM_011617	RefSeq \| MGI Sequence Detail	842	ZRU/MplStud
polypeptide	O55237	UniProt \| EBI \| MGI Sequence Detail	195	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001309 CD70 molecule

(term hierarchy)
InterPro Domains

IPR042374 CD70 antigen

IPR006052 Tumour necrosis factor domain

IPR008983 Tumour necrosis factor-like domain superfamily
GlyGen

O55237 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 8

Genomic 1

cDNA 7

Microarray probesets 3

Summaries

All 99

Developmental Gene Expression 1

Gene Ontology 9

Phenotypes 39
Earliest

J:43979 Tesselaar K, et al., Characterization of murine CD70, the ligand of the TNF receptor family member CD27. J Immunol. 1997 Nov 15;159(10):4959-65
Latest

J:391213 Vleeshouwers W, et al., Dendritic cell circadian clocks shape memory CD8(+) T cell differentiation. Sci Adv. 2026 Jul 31;12(31):eaeh3719

TSS for Cd70:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148902	Chr17:57456633-57456637 (-)	142 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24