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Rbbp7 Gene Detail
Summary
  • Symbol
    Rbbp7
  • Name
    retinoblastoma binding protein 7, chromatin remodeling factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194910
    NCBI Gene: 245688
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:161543398-161562088 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 74.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194910
 protein coding gene ChrX:161543368-161562088 (+)
129S1/SvImJ ENSMUSG00200025594
 protein coding gene ChrX:138270759-138289451 (+)
A/J ENSMUSG00195035799
 protein coding gene ChrX:143391093-143409784 (+)
AKR/J ENSMUSG00220027521
 protein coding gene ChrX:135246676-135265355 (+)
BALB/cJ ENSMUSG00180040161
 protein coding gene ChrX:138762968-138781649 (+)
C3H/HeJ ENSMUSG00175025265
 protein coding gene ChrX:143326835-143345527 (+)
C57BL/6NJ ENSMUSG00215016641
 protein coding gene ChrX:139161191-139179883 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033547
 protein coding gene ChrX:151084588-151102178 (+)
CAST/EiJ ENSTCUG00005031964
 protein coding gene ChrX:140894867-140913559 (+)
CBA/J ENSMUSG00210033868
 protein coding gene ChrX:140669088-140687777 (+)
DBA/2J ENSMUSG00185029913
 protein coding gene ChrX:155597720-155616411 (+)
FVB/NJ ENSMUSG00205023570
 protein coding gene ChrX:139254763-139273455 (+)
JF1/MsJ ENSUMUG00000019616
 protein coding gene ChrX:175991204-176009865 (+)
LP/J ENSMUSG00230024644
 protein coding gene ChrX:162387053-162405743 (+)
NOD/ShiLtJ ENSMUSG00190032153
 protein coding gene ChrX:139773920-139792611 (+)
NZO/HlLtJ ENSMUSG00225037734
 protein coding gene ChrX:165776306-165794997 (+)
PWK/PhJ ENSLUMG00010038119
 protein coding gene ChrX:137068655-137087316 (+)
SPRET/EiJ ENSMSPG00010018333
 protein coding gene ChrX:142205160-142223933 (+)
WSB/EiJ ENSIUOG00005024001
 protein coding gene ChrX:140071882-140090471 (+)



Homology
more
  • Human Ortholog
    RBBP7, RB binding protein 7, chromatin remodeling factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBBP7, RB binding protein 7, chromatin remodeling factor
  • Synonyms
    RbAp46, SPGFX9
  • Links
    NCBI Gene ID: 5931
    UniProt: Q16576

  • Chr Location
    Xp22.2; chrX:16839283-16870372 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RBBP7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit posterior patterning and embryo turning defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    63
  • cDNA Data
    34
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031353 Ensembl Gene Model | MGI Sequence Detail 18691 C57BL/6J ±  kb
    transcript ENSMUST00000033720 Ensembl | MGI Sequence Detail 2244 Not Applicable  
    polypeptide ENSMUSP00000033720 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000013779 histone-binding protein RBBP7
      (term hierarchy)
    • InterPro Domains
      IPR022052 Histone-binding protein RBBP4-like, N-terminal
      IPR020472 PAC1/LIS1-like, WD-40 repeat
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
      IPR050459 WD repeat RBAP46/RBAP48/MSI1
    • GlyGen
      Q60973 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 35
      Primer pair 2
      Other 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147827, MGI:2147849, MGI:2147961, MGI:2148033
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 16
      Gene Ontology 23
      Phenotypes 16
    • Earliest
      J:43395 Qian YW, et al., Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. J Biol Chem. 1995 Oct 27;270(43):25507-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory