C1qbp MGI Mouse Gene Detail - MGI:1194505 - complement component 1, q subcomponent binding protein

Symbol

C1qbp
Name

complement component 1, q subcomponent binding protein
Synonyms

D11Wsu182e, HABP1, P32

Feature Type

protein coding gene
IDs

MGI:1194505
NCBI Gene: 12261
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:70868672-70873852 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 43.21 cM
Mapping Data

8 experiments

SNPs within 2kb

39 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194505	protein coding gene	Chr11:70868662-70873852 (-)
129S1/SvImJ	ENSMUSG00200047068	protein coding gene	Chr11:67815991-67821219 (-)
A/J	ENSMUSG00195052081	protein coding gene	Chr11:67842409-67847600 (-)
AKR/J	ENSMUSG00220054049	protein coding gene	Chr11:67959768-67965002 (-)
BALB/cJ	ENSMUSG00180053555	protein coding gene	Chr11:67913913-67919140 (-)
C3H/HeJ	ENSMUSG00175053661	protein coding gene	Chr11:67861230-67866458 (-)
C57BL/6NJ	ENSMUSG00215049529	protein coding gene	Chr11:67638219-67643409 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016656	protein coding gene	Chr11:65739254-65744715 (-)
CAST/EiJ	ENSTCUG00005053581	protein coding gene	Chr11:67406040-67411236 (-)
CBA/J	ENSMUSG00210051444	protein coding gene	Chr11:67715310-67720537 (-)
DBA/2J	ENSMUSG00185043026	protein coding gene	Chr11:67953892-67959110 (-)
FVB/NJ	ENSMUSG00205028953	protein coding gene	Chr11:67808583-67813801 (-)
JF1/MsJ	ENSUMUG00000056451	protein coding gene	Chr11:68352465-68357683 (-)
LP/J	ENSMUSG00230052954	protein coding gene	Chr11:69026507-69031734 (-)
NOD/ShiLtJ	ENSMUSG00190053996	protein coding gene	Chr11:67948848-67954080 (-)
NZO/HlLtJ	ENSMUSG00225036331	protein coding gene	Chr11:71207713-71212940 (-)
PWK/PhJ	ENSLUMG00010053353	protein coding gene	Chr11:67820530-67825749 (-)
SPRET/EiJ	ENSMSPG00010047233	protein coding gene	Chr11:68553960-68559159 (-)
WSB/EiJ	ENSIUOG00005039837	protein coding gene	Chr11:67840763-67845985 (-)

Human Ortholog

C1QBP, complement C1q binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

C1QBP, complement C1q binding protein
Synonyms

COXPD33, GC1QBP, gC1qR, gC1Q-R, HABP1, p32, SF2AP32, SF2p32
Links

HGNC:1243

NCBI Gene ID: 708

UniProt: Q07021
Chr Location

17p13.2; chr17:5432777-5448830 (-) GRCh38

MGI Vertebrate Homology

C1qbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: C1QBP
Gene Tree

C1qbp

Diseases

1 with human C1QBP associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 33 IDs combined oxidative phosphorylation deficiency 33 DOID:0111495 OMIM:617713

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
34 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

15
Targeted

10
Genomic Mutations

2 involving C1qbp
Find Mice (IMSR)

23 strains or lines available

Mice homozygous for a knock-out allele exhibit embryonic lethality by E11.5 with poor development, small embryo size, pale and anemic organs, poor cellular proliferation and impaired mitochondrial electron transport chain function.

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All GO Annotations

86
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

832
Tissues

114
cDNA Data

153
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase c1qbp

ZFIN c1qbp

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All Sequences

46
RefSeq

2
UniProt

3
CCDS

CCDS24970.1

Ensembl

ENSMUSG00000018446 (Evidence)
NCBI Gene

12261

			Length	Strain/Species	Flank
genomic	12261	NCBI Gene Model \| MGI Sequence Detail	5181	C57BL/6J	± kb
transcript	NM_007573	RefSeq \| MGI Sequence Detail	1177	ZRU/MplStud
polypeptide	O35658	UniProt \| EBI \| MGI Sequence Detail	278	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004877 complement component 1 Q subcomponent-binding protein, mitochondrial

(term hierarchy)
InterPro Domains

IPR003428 Mitochondrial glycoprotein

IPR036561 Mitochondrial glycoprotein superfamily
GlyGen

O35658 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 162

Genomic 7

cDNA 153

Primer pair 2

Microarray probesets 4

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MGD-MRK-36447, MGI:107870, MGI:2143969, MGI:2144060

Summaries

All 105

Developmental Gene Expression 7

Gene Ontology 12

Phenotypes 34
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:387190 Fang Y, et al., TUT1-catalyzed U6 snRNA 3'-end maturation is essential for RNA splicing and stem cell survival. EMBO Rep. 2026 May;27(10):2703-2730

TSS for C1qbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109049	Chr11:70873813-70873850 (-)	20 bp
Tssr109048	Chr11:70873773-70873811 (-)	60 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24