Hdgf MGI Mouse Gene Detail - MGI:1194494 - heparin binding growth factor

Symbol

Hdgf
Name

heparin binding growth factor
Synonyms

D3Ertd299e

Feature Type

protein coding gene
IDs

MGI:1194494
NCBI Gene: 15191
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr3:87813844-87823439 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM
Mapping Data

3 experiments

SNPs within 2kb

354 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194494	protein coding gene	Chr3:87813628-87823439 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027372	protein coding gene	Chr3:88035298-88046174 (+)
A/J	MGP_AJ_G0027336	protein coding gene	Chr3:85048717-85058229 (+)
AKR/J	MGP_AKRJ_G0027302	protein coding gene	Chr3:87143451-87152962 (+)
BALB/cJ	MGP_BALBcJ_G0027345	protein coding gene	Chr3:85143991-85153500 (+)
C3H/HeJ	MGP_C3HHeJ_G0027088	protein coding gene	Chr3:87413124-87422639 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027791	protein coding gene	Chr3:91278901-91288450 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025144	protein coding gene	Chr3:80671375-80680788 (+)
CAST/EiJ	MGP_CASTEiJ_G0026535	protein coding gene	Chr3:87619815-87629636 (+)
CBA/J	MGP_CBAJ_G0027063	protein coding gene	Chr3:94369095-94378605 (+)
DBA/2J	MGP_DBA2J_G0027199	protein coding gene	Chr3:84541271-84550796 (+)
FVB/NJ	MGP_FVBNJ_G0027168	protein coding gene	Chr3:82814223-82823741 (+)
LP/J	MGP_LPJ_G0027307	protein coding gene	Chr3:89000303-89009802 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027187	protein coding gene	Chr3:100617596-100627121 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027849	protein coding gene	Chr3:86889973-86899799 (+)
PWK/PhJ	MGP_PWKPhJ_G0026268	protein coding gene	Chr3:84335427-84345383 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026085	protein coding gene	Chr3:86078207-86086816 (+)
WSB/EiJ	MGP_WSBEiJ_G0026614	protein coding gene	Chr3:87254757-87264273 (+)

Human Ortholog

HDGF, heparin binding growth factor

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HDGF, heparin binding growth factor
Synonyms

HMG1L2
Links

HGNC:4856

NCBI Gene ID: 3068

UniProt: P51858
Chr Location

1q23.1; chr1:156742107-156767366 (-) GRCh38

MGI Vertebrate Homology

Hdgf stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: HDGF
Gene Tree

Hdgf

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

119
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

113
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Hdgf
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

58 strains or lines available

Mice homozygous for a targeted disruption of this gene are viable and fertile and display no major morphological, biochemical or behavioral phenotypes except for a significant reduction in rearing activity.

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All GO Annotations

43
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

55
cDNA Data

290
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hdgf

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All Sequences

89
RefSeq

28
UniProt

4
CCDS

CCDS17457.1

Ensembl

ENSMUSG00000004897 (Evidence)
NCBI Gene

15191

			Length	Strain/Species	Flank
genomic	15191	NCBI Gene Model \| MGI Sequence Detail	9596	C57BL/6J	± kb
transcript	NM_001410039	RefSeq \| MGI Sequence Detail	2202	ZRU/MplStud
polypeptide	P51859	UniProt \| EBI \| MGI Sequence Detail	237	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000008490 hepatoma-derived growth factor

(term hierarchy)
InterPro Domains

IPR047363 Hepatoma-derived growth factor, PWWP domain

IPR000313 PWWP domain
GlyGen

P51859 1 site, 1 O-linked glycan (1 site)

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All nucleic 293

cDNA 291

Primer pair 2

Microarray probesets 8

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MGI:1098788, MGI:2139627

Summaries

All 60

Developmental Gene Expression 11

Diseases 1

Gene Ontology 13

Phenotypes 15
Earliest

J:42918 Izumoto Y, et al., Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus. Biochem Biophys Res Commun. 1997 Sep 8;238(1):26-32
Latest

J:358217 Hu TH, et al., HDGF stimulates liver tumorigenesis by enhancing reactive oxygen species generation in mitochondria. J Biol Chem. 2023 Oct 10;299(11):105335

TSS for Hdgf:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr927	Chr3:87813377-87813398 (+)	-456 bp
Tssr928	Chr3:87813434-87813452 (+)	-401 bp
Tssr929	Chr3:87813464-87813477 (+)	-373 bp
Tssr29842	Chr3:87813624-87813633 (+)	-215 bp
Tssr29843	Chr3:87813640-87813663 (+)	-192 bp
Tssr29844	Chr3:87813669-87813721 (+)	-149 bp
Tssr29845	Chr3:87813837-87813914 (+)	32 bp
Tssr29846	Chr3:87813915-87813944 (+)	86 bp
Tssr29847	Chr3:87814149-87814163 (+)	312 bp
Tssr29848	Chr3:87814198-87814216 (+)	363 bp
Tssr29849	Chr3:87814220-87814240 (+)	386 bp
Tssr29850	Chr3:87822225-87822252 (+)	8,395 bp
Tssr29851	Chr3:87822363-87822387 (+)	8,531 bp
Tssr29852	Chr3:87822388-87822402 (+)	8,551 bp
Tssr29853	Chr3:87822468-87822490 (+)	8,635 bp
Tssr29854	Chr3:87822583-87822634 (+)	8,765 bp
Tssr29855	Chr3:87822791-87822819 (+)	8,961 bp
Tssr29856	Chr3:87822844-87822855 (+)	9,006 bp
Tssr29857	Chr3:87822867-87822879 (+)	9,029 bp
Tssr29858	Chr3:87822885-87822910 (+)	9,054 bp
Tssr29859	Chr3:87822919-87822942 (+)	9,087 bp
Tssr29860	Chr3:87823057-87823090 (+)	9,230 bp
Tssr29861	Chr3:87823096-87823112 (+)	9,260 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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