About   Help   FAQ
Guca1b Gene Detail
Summary
  • Symbol
    Guca1b
  • Name
    guanylate cyclase activator 1B
  • Synonyms
    GCAP2, GCAP2 (retina)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194489
    NCBI Gene: 107477
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47696318-47703892 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    328 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194489
 protein coding gene Chr17:47692526-47703892 (+)
129S1/SvImJ ENSMUSG00200027182
 protein coding gene Chr17:42898968-42906519 (+)
A/J ENSMUSG00195020715
 protein coding gene Chr17:44399895-44407465 (+)
AKR/J ENSMUSG00220033602
 protein coding gene Chr17:43393277-43400822 (+)
BALB/cJ ENSMUSG00180020581
 protein coding gene Chr17:44149632-44157179 (+)
C3H/HeJ ENSMUSG00175016091
 protein coding gene Chr17:43463875-43471445 (+)
C57BL/6NJ ENSMUSG00215017114
 protein coding gene Chr17:43019274-43026850 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021697
 protein coding gene Chr17:44081540-44089009 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210032341
 protein coding gene Chr17:43213506-43221078 (+)
DBA/2J ENSMUSG00185028149
 protein coding gene Chr17:46112471-46120043 (+)
FVB/NJ ENSMUSG00205024089
 protein coding gene Chr17:43686415-43693966 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230037311
 protein coding gene Chr17:47010978-47018517 (+)
NOD/ShiLtJ ENSMUSG00190017182
 protein coding gene Chr17:43104443-43112017 (+)
NZO/HlLtJ ENSMUSG00225041905
 protein coding gene Chr17:49265460-49273001 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GUCA1B, guanylate cyclase activator 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GUCA1B, guanylate cyclase activator 1B
  • Synonyms
    GCAP 2, GCAP-2, GCAP2, GCAP-II, GUCA2, RP48
  • Links
    NCBI Gene ID: 2979
    UniProt: Q9UMX6

  • Chr Location
    6p21.1; chr6:42183284-42194956 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GUCA1B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal rod electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    4
  • cDNA Data
    80
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023979 Ensembl Gene Model | MGI Sequence Detail 7575 C57BL/6J ±  kb
transcript ENSMUST00000145462 Ensembl | MGI Sequence Detail 1556 Not Applicable  
polypeptide ENSMUSP00000126799 Ensembl | MGI Sequence Detail 230 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 86
    Genomic 4
    cDNA 81
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18680, MGI:101856, MGI:2385056
References
more
  • Summaries
    All 80
    Developmental Gene Expression 4
    Gene Ontology 14
    Phenotypes 44
  • Earliest
    J:47304 Howes K, et al., Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Invest Ophthalmol Vis Sci. 1998 May;39(6):867-75
  • Latest
    J:388074 Peshenko IV, et al., Protein inhibitor of retinal membrane guanylyl cyclase suppresses cGMP synthesis in photoreceptors. J Biol Chem. 2025 Sep 15;301(10):110718
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory