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Npepps Gene Detail
Summary
  • Symbol
    Npepps
  • Name
    aminopeptidase puromycin sensitive
  • Synonyms
    MP100, Psa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101358
    NCBI Gene: 19155
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97096668-97171464 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.95 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1637 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101358
 protein coding gene Chr11:97096668-97171503 (-)
129S1/SvImJ ENSMUSG00200050276
 protein coding gene Chr11:94343550-94418354 (-)
A/J ENSMUSG00195050155
 protein coding gene Chr11:94067100-94142599 (-)
AKR/J ENSMUSG00220050266
 protein coding gene Chr11:94326242-94401724 (-)
BALB/cJ ENSMUSG00180042903
 protein coding gene Chr11:94324942-94400192 (-)
C3H/HeJ ENSMUSG00175045115
 protein coding gene Chr11:94323618-94398423 (-)
C57BL/6NJ ENSMUSG00215053096
 protein coding gene Chr11:93914456-93989263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017051
 protein coding gene Chr11:92979630-93058789 (-)
CAST/EiJ ENSTCUG00005045410
 protein coding gene Chr11:93777114-93852248 (-)
CBA/J ENSMUSG00210053239
 protein coding gene Chr11:94029274-94104738 (-)
DBA/2J ENSMUSG00185042399
 protein coding gene Chr11:94373538-94448335 (-)
FVB/NJ ENSMUSG00205026027
 protein coding gene Chr11:94227176-94302430 (-)
JF1/MsJ ENSUMUG00000038970
 protein coding gene Chr11:94683593-94759066 (-)
LP/J ENSMUSG00230050039
 protein coding gene Chr11:95426525-95501333 (-)
NOD/ShiLtJ ENSMUSG00190050610
 protein coding gene Chr11:94417084-94492522 (-)
NZO/HlLtJ ENSMUSG00225050754
 protein coding gene Chr11:97480718-97555969 (-)
PWK/PhJ ENSLUMG00010043531
 protein coding gene Chr11:94227138-94302441 (-)
SPRET/EiJ ENSMSPG00010048645
 protein coding gene Chr11:94725717-94799608 (-)
WSB/EiJ ENSIUOG00005047079
 protein coding gene Chr11:94172928-94248165 (-)



Homology
more
  • Human Ortholog
    NPEPPS, aminopeptidase puromycin sensitive
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPEPPS, aminopeptidase puromycin sensitive
  • Synonyms
    AAP-S, MP100, PSA
  • Links
    NCBI Gene ID: 9520
    UniProt: P55786

  • Chr Location
    17q21.32; chr17:47522933-47624665 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 3 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a gene-trapped mutation exhibit dwarfism, increased anxiety, decreased pain sensitivity, and infertility in both sexes. Females fail to produce the corpus luteum of pregnancy, while males fail to copulate and have impaired spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    103
  • cDNA Data
    184
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001441 Ensembl Gene Model | MGI Sequence Detail 74797 C57BL/6J ±  kb
    transcript ENSMUST00000001480 Ensembl | MGI Sequence Detail 4215 Not Applicable  
    polypeptide ENSMUSP00000001480 Ensembl | MGI Sequence Detail 920 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 188
      cDNA 185
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144698, MGI:2673208
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:43396 Constam DB, et al., Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization. J Biol Chem. 1995 Nov 10;270(45):26931-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory