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Nmbr Gene Detail
Summary
  • Symbol
    Nmbr
  • Name
    neuromedin B receptor
Location &
Maps
more
  • Sequence Map
    Chr10:14634894-14647202 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 5.50 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    469 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100525
 protein coding gene Chr10:14581335-14647202 (+)
129S1/SvImJ ENSMUSG00200009163
 protein coding gene Chr10:11658584-11669263 (+)
A/J ENSMUSG00195006753
 protein coding gene Chr10:11581379-11592074 (+)
AKR/J ENSMUSG00220009982
 protein coding gene Chr10:11544783-11556327 (+)
BALB/cJ ENSMUSG00180014499
 protein coding gene Chr10:11738306-11749009 (+)
C3H/HeJ ENSMUSG00175019335
 protein coding gene Chr10:11734460-11745155 (+)
C57BL/6NJ ENSMUSG00215003375
 protein coding gene Chr10:11591364-11602047 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015132
 protein coding gene Chr10:10944847-11006106 (+)
CAST/EiJ ENSTCUG00005029031
 protein coding gene Chr10:11573800-11584457 (+)
CBA/J ENSMUSG00210015464
 protein coding gene Chr10:11684136-11694831 (+)
DBA/2J ENSMUSG00185007154
 protein coding gene Chr10:11714874-11725474 (+)
FVB/NJ ENSMUSG00205014600
 protein coding gene Chr10:11768774-11779454 (+)
JF1/MsJ ENSUMUG00000012023
 protein coding gene Chr10:11757310-11767912 (+)
LP/J ENSMUSG00230015168
 protein coding gene Chr10:13337397-13348096 (+)
NOD/ShiLtJ ENSMUSG00190010759
 protein coding gene Chr10:11716243-11726922 (+)
NZO/HlLtJ ENSMUSG00225015979
 protein coding gene Chr10:17853881-17864564 (+)
PWK/PhJ ENSLUMG00010015171
 protein coding gene Chr10:11482088-11492723 (+)
SPRET/EiJ ENSMSPG00010010152
 protein coding gene Chr10:11945179-11966329 (+)
WSB/EiJ ENSIUOG00005021606
 protein coding gene Chr10:11319760-11330450 (+)



Homology
more
  • Human Ortholog
    NMBR, neuromedin B receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMBR, neuromedin B receptor
  • Synonyms
    BB1, BB1R, BRS1, NMB-R
  • Links
    NCBI Gene ID: 4829
    UniProt: P28336

  • Chr Location
    6q24.1; chr6:142058330-142147122 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a 50% reduction in the thermoregulatory response to neuromedin B as well as impaired maternal behavior in response to restraint-induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    622
  • Tissues
    20
  • cDNA Data
    5
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18101 NCBI Gene Model | MGI Sequence Detail 12309 C57BL/6J ±  kb
transcript NM_008703 RefSeq | MGI Sequence Detail 2417 C57BL/6  
polypeptide O54799 UniProt | EBI | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143902
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 20
  • Earliest
    J:41803 Ohki-Hamazaki H, et al., Cloning and expression of the neuromedin B receptor and the third subtype of bombesin receptor genes in the mouse. Brain Res. 1997 Jul 11;762(1-2):165-72
  • Latest
    J:369761 Cui Y, et al., Sigh generation in preBotzinger complex. Elife. 2025 Jun 24;13
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory