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Slc7a3 Gene Detail
Summary
  • Symbol
    Slc7a3
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 3
  • Synonyms
    Atrc3, Cat3, SLC7A1, SLC7A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100521
    NCBI Gene: 11989
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:100122816-100129626 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 43.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100521
protein coding gene ChrX:100122752-100134058 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035951
protein coding gene ChrX:97561391-97569571 (-)
A/J MGP_AJ_G0035936
protein coding gene ChrX:97576700-97584994 (-)
AKR/J MGP_AKRJ_G0035852
protein coding gene ChrX:100369358-100378174 (-)
BALB/cJ MGP_BALBcJ_G0035919
protein coding gene ChrX:96324431-96330896 (-)
C3H/HeJ MGP_C3HHeJ_G0035628
protein coding gene ChrX:97971758-97979066 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036448
protein coding gene ChrX:100470068-100479358 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033278
protein coding gene ChrX:95331707-95338063 (-)
CAST/EiJ MGP_CASTEiJ_G0034915
protein coding gene ChrX:82280607-82287476 (-)
CBA/J MGP_CBAJ_G0035603
protein coding gene ChrX:103585471-103592287 (-)
DBA/2J MGP_DBA2J_G0035757
protein coding gene ChrX:96790102-96796910 (-)
FVB/NJ MGP_FVBNJ_G0035695
protein coding gene ChrX:96180202-96187044 (-)
LP/J MGP_LPJ_G0035847
protein coding gene ChrX:98528060-98535143 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035730
protein coding gene ChrX:108135619-108143150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036475
protein coding gene ChrX:97265882-97272711 (-)
PWK/PhJ MGP_PWKPhJ_G0034614
protein coding gene ChrX:79891673-79898617 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034442
protein coding gene ChrX:83173871-83180574 (-)
WSB/EiJ MGP_WSBEiJ_G0035054
protein coding gene ChrX:95972443-95980936 (-)



Homology
more
  • Human Ortholog
    SLC7A3, solute carrier family 7 member 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC7A3, solute carrier family 7 member 3
  • Synonyms
    ATRC3, CAT-3, CAT3
  • Links
    NCBI Gene ID: 84889
    neXtProt AC: NX_Q8WY07
    UniProt: Q8WY07

  • Chr Location
    Xq13.1; chrX:70925579-70931125 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Mice homozygous for a null allele exhibit normal and malignant hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031297 Ensembl Gene Model | MGI Sequence Detail 6811 C57BL/6J ±  kb
transcript ENSMUST00000113710 Ensembl | MGI Sequence Detail 2750 Not Applicable  
polypeptide ENSMUSP00000109339 Ensembl | MGI Sequence Detail 618 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 29
    Primer pair 6

    Microarray probesets 5
References
more
  • Summaries
    All 38
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:43574 Ito K, et al., A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain. J Biol Chem. 1997 Oct 17;272(42):26780-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory