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Hip1 Gene Detail
Summary
  • Symbol
    Hip1
  • Name
    huntingtin interacting protein 1
  • Synonyms
    2610109B09Rik, A930014B11Rik, E130315I21Rik, HIP-1, MGC:27616
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099804
    NCBI Gene: 215114
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:135435385-135573974 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.18 cM, cytoband F-G2
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    640 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099804
 protein coding gene Chr5:135435350-135574167 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030183
 protein coding gene Chr5:139935313-140091868 (-)
A/J MGP_AJ_G0030151
 protein coding gene Chr5:133949455-134098737 (-)
AKR/J MGP_AKRJ_G0030084
 protein coding gene Chr5:138296817-138446414 (-)
BALB/cJ MGP_BALBcJ_G0030161
 protein coding gene Chr5:135296848-135437355 (-)
C3H/HeJ MGP_C3HHeJ_G0029877
 protein coding gene Chr5:138863915-139009766 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030614
 protein coding gene Chr5:145157640-145314872 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027837
 protein coding gene Chr5:128239643-128382351 (-)
CAST/EiJ MGP_CASTEiJ_G0029286
 protein coding gene Chr5:138272637-138419753 (-)
CBA/J MGP_CBAJ_G0029847
 protein coding gene Chr5:150855459-151001287 (-)
DBA/2J MGP_DBA2J_G0029998
 protein coding gene Chr5:133851866-133992886 (-)
FVB/NJ MGP_FVBNJ_G0029953
 protein coding gene Chr5:132985216-133132685 (-)
LP/J MGP_LPJ_G0030086
 protein coding gene Chr5:140389322-140535725 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029985
 protein coding gene Chr5:153847169-153991502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030654
 protein coding gene Chr5:138044580-138202380 (-)
PWK/PhJ MGP_PWKPhJ_G0029001
 protein coding gene Chr5:132888976-133037011 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028836
 protein coding gene Chr5:135601308-135747104 (-)
WSB/EiJ MGP_WSBEiJ_G0029360
 protein coding gene Chr5:138796374-138941324 (-)



Homology
more
  • Human Ortholog
    HIP1, huntingtin interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIP1, huntingtin interacting protein 1
  • Synonyms
    HIP-I, ILWEQ, SHON, SHONbeta, SHONgamma
  • Links
    NCBI Gene ID: 3092
    neXtProt AC: NX_O00291
    UniProt: O00291

  • Chr Location
    7q11.23; chr7:75533298-75738962 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 7 alleles in 5 genetic backgrounds
    45 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants may exhibit axial skeleton defects, hematopotietic abnormalities, and testicular degeneration with increased apoptosis of postmeiotic spermatids. One line showed microphthalmia and cataracts, whereas others did not.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    19
  • cDNA Data
    125
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039959 Ensembl Gene Model | MGI Sequence Detail 138590 C57BL/6J ±  kb
    transcript ENSMUST00000060311 Ensembl | MGI Sequence Detail 7835 Not Applicable  
    polypeptide ENSMUSP00000059033 Ensembl | MGI Sequence Detail 1029 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      Genomic 10
      cDNA 128
      Primer pair 2
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1924028, MGI:1924349, MGI:2443720
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 7
      Gene Ontology 14
      Phenotypes 27
    • Earliest
      J:43669 Himmelbauer H, et al., IRS-PCR-based mapping of the Huntingtin interacting protein (HIP1) on mouse Chromosome 5. Mamm Genome. 1998 Jan;9(1):26-31
    • Latest
      J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory