Ptpn4 MGI Mouse Gene Detail - MGI:1099792 - protein tyrosine phosphatase, non-receptor type 4

Symbol

Ptpn4
Name

protein tyrosine phosphatase, non-receptor type 4
Synonyms

hPTP-MEG, protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte), PTPMEG, TEP, TEP/mPTPMEG, testis-enriched phosphatase

Feature Type

protein coding gene
IDs

MGI:1099792
NCBI Gene: 19258
Alliance

genome feature page
Transcription Start Sites

8 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr1:119580197-119765281 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 52.39 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

2939 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1099792	protein coding gene	Chr1:119580197-119765343 (-)
129S1/SvImJ	ENSMUSG00200001560	protein coding gene	Chr1:117056857-117206754 (-)
A/J	ENSMUSG00195004113	protein coding gene	Chr1:116297667-116447541 (-)
AKR/J	ENSMUSG00220024034	protein coding gene	Chr1:116110803-116263241 (-)
BALB/cJ	ENSMUSG00180012141	protein coding gene	Chr1:116703054-116852915 (-)
C3H/HeJ	ENSMUSG00175019045	protein coding gene	Chr1:116528539-116678391 (-)
C57BL/6NJ	ENSMUSG00215010254	protein coding gene	Chr1:116487344-116637364 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014515	protein coding gene	Chr1:111685951-111865164 (-)
CAST/EiJ	ENSTCUG00005006404	protein coding gene	Chr1:115452957-115602630 (-)
CBA/J	ENSMUSG00210001001	protein coding gene	Chr1:116358190-116508046 (-)
DBA/2J	ENSMUSG00185013329	protein coding gene	Chr1:120806489-120956374 (-)
FVB/NJ	ENSMUSG00205011411	protein coding gene	Chr1:115856284-116006146 (-)
JF1/MsJ	ENSUMUG00000024823	protein coding gene	Chr1:119911002-120047434 (-)
LP/J	ENSMUSG00230008742	protein coding gene	Chr1:120234688-120384570 (-)
NOD/ShiLtJ	ENSMUSG00190006056	protein coding gene	Chr1:116343379-116493241 (-)
NZO/HlLtJ	ENSMUSG00225004449	protein coding gene	Chr1:124025840-124175683 (-)
PWK/PhJ	ENSLUMG00010013979	protein coding gene	Chr1:115488372-115624762 (-)
SPRET/EiJ	ENSMSPG00010016186	protein coding gene	Chr1:118126132-118305706 (-)
WSB/EiJ	ENSIUOG00005002947	protein coding gene	Chr1:116206679-116356554 (-)

Human Ortholog

PTPN4, protein tyrosine phosphatase non-receptor type 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN4, protein tyrosine phosphatase non-receptor type 4
Synonyms

MEG, PTPMEG, PTPMEG1
Links

HGNC:9656

NCBI Gene ID: 5775

UniProt: P29074
Chr Location

2q14.2; chr2:119759604-119984899 (+) GRCh38

MGI Vertebrate Homology

Ptpn4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PTPN4
Protein SuperFamily

Tyr-Ptase_nr3
Gene Tree

Ptpn4

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

14
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Ptpn4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

51 strains or lines available

Mice homozygous for a null allele exhibit impaired coordination, abnormal eye blink conditioning behavior, and reduced long term depression.

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All GO Annotations

22
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

699
Tissues

40
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ptpn4

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All Sequences

81
RefSeq

20
UniProt

12
CCDS

CCDS15227.1

Ensembl

ENSMUSG00000026384 (Evidence)
NCBI Gene

19258

			Length	Strain/Species	Flank
genomic	19258	NCBI Gene Model \| MGI Sequence Detail	185085	C57BL/6J	± kb
transcript	NM_019933	RefSeq \| MGI Sequence Detail	4707	ZRU/MplStud
polypeptide	Q9WU22	UniProt \| EBI \| MGI Sequence Detail	926	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000013459 tyrosine-protein phosphatase non-receptor type 4

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR019749 Band 4.1 domain

IPR000798 Ezrin/radixin/moesin-like

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR014847 FERM adjacent

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR011993 PH-like domain superfamily

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4

IPR041783 PTPN3/4, FERM domain C-lobe

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q9WU22 1 site

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All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 16
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10

TSS for Ptpn4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13225	Chr1:119765397-119765403 (-)	-119 bp
Tssr13224	Chr1:119765196-119765285 (-)	40 bp
Tssr13223	Chr1:119765068-119765116 (-)	189 bp
Tssr13222	Chr1:119765049-119765058 (-)	227 bp
Tssr13221	Chr1:119765018-119765029 (-)	257 bp
Tssr13220	Chr1:119764818-119764869 (-)	437 bp
Tssr13219	Chr1:119755817-119755822 (-)	9,461 bp
Tssr13218	Chr1:119749042-119749046 (-)	16,237 bp

Ptpn4 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lore1	Chr1, 44.69 cM	Chr1:75549191-92941077	J:93175	Potential candidate genes mapping near Lore1 on mouse Chromosome 1 are Pthr2, Ptpn4, Zfp142 (41.5 cM), and Htr5b (63 cM). Pthr2, Ptpn4, and Zfp142 have been sequenced and are polymorphic between inbred strains LS and IS.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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