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Ucp3 Gene Detail
Summary
  • Symbol
    Ucp3
  • Name
    uncoupling protein 3 (mitochondrial, proton carrier)
  • Synonyms
    Slc25a9, UCP-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099787
    NCBI Gene: 22229
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100122198-100135639 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099787
 protein coding gene Chr7:100122197-100135639 (+)
129S1/SvImJ ENSMUSG00200047184
 protein coding gene Chr7:86950721-86964588 (+)
A/J ENSMUSG00195053719
 protein coding gene Chr7:91456178-91470044 (+)
AKR/J ENSMUSG00220049957
 protein coding gene Chr7:84872819-84886687 (+)
BALB/cJ ENSMUSG00180028411
 protein coding gene Chr7:88129172-88143039 (+)
C3H/HeJ ENSMUSG00175023342
 protein coding gene Chr7:88783695-88797438 (+)
C57BL/6NJ ENSMUSG00215014708
 protein coding gene Chr7:87968291-87982136 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030046
 protein coding gene Chr7:103158645-103172151 (+)
CAST/EiJ ENSTCUG00005053035
 protein coding gene Chr7:91373003-91386724 (+)
CBA/J ENSMUSG00210024490
 protein coding gene Chr7:88637379-88651124 (+)
DBA/2J ENSMUSG00185056637
 protein coding gene Chr7:92958830-92972577 (+)
FVB/NJ ENSMUSG00205017540
 protein coding gene Chr7:88627302-88641170 (+)
JF1/MsJ ENSUMUG00000047442
 protein coding gene Chr7:97863767-97877513 (+)
LP/J ENSMUSG00230038481
 protein coding gene Chr7:99092475-99106340 (+)
NOD/ShiLtJ ENSMUSG00190020088
 protein coding gene Chr7:88910039-88923927 (+)
NZO/HlLtJ ENSMUSG00225050400
 protein coding gene Chr7:97270519-97284375 (+)
PWK/PhJ ENSLUMG00010040601
 protein coding gene Chr7:87103683-87117347 (+)
SPRET/EiJ ENSMSPG00010009545
 protein coding gene Chr7:88349390-88363345 (+)
WSB/EiJ ENSIUOG00005009908
 protein coding gene Chr7:89257362-89271218 (+)



Homology
more
  • Human Ortholog
    UCP3, uncoupling protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCP3, uncoupling protein 3
  • Synonyms
    SLC25A9
  • Links
    NCBI Gene ID: 7352
    UniProt: P55916

  • Chr Location
    11q13.4; chr11:74000277-74009085 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human UCP3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit a lack of superoxide-induced uncoupling in skeletal muscle mitochondria, accompanied by increased reactive oxygen species formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    640
  • Tissues
    22
  • cDNA Data
    22
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22229 NCBI Gene Model | MGI Sequence Detail 13442 C57BL/6J ±  kb
    transcript NM_009464 RefSeq | MGI Sequence Detail 2448 ZRU/MplStud  
    polypeptide P56501 UniProt | EBI | MGI Sequence Detail 308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000017037 putative mitochondrial transporter UCP3
      (term hierarchy)
    • InterPro Domains
      IPR002067 Mitochondrial carrier protein
      IPR023395 Mitochondrial carrier protein domain superfamily
      IPR018108 Mitochondrial carrier protein, transmembrane region
      IPR050391 Mitochondrial Metabolite Transporter
    • GlyGen
      P56501 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 2
      cDNA 23
      Primer pair 5
      Other 1
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2142016
    References
    more
    • Summaries
      All 171
      Developmental Gene Expression 20
      Gene Ontology 16
      Phenotypes 47
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:390486 Codella R, et al., Overexpression of UCP3 decreases mitochondrial efficiency in mouse skeletal muscle in vivo. FEBS Lett. 2023 Jan;597(2):309-319
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory