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Ccl25 Gene Detail
Summary
  • Symbol
    Ccl25
  • Name
    C-C motif chemokine ligand 25
  • Synonyms
    CKb15, Scya25, TECK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099448
    NCBI Gene: 20300
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:4375210-4410020 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 2.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    928 from dbSNP Build 142
  • Strain Annotations
    26
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1099448
 protein coding gene Chr8:4375207-4410020 (+)
129S1/SvImJ ENSMUSG00200009876
 protein coding gene Chr8:1226541-1236869 (+)
129S1/SvImJ ENSMUSGG00200054558
 protein coding gene Chr8:1202193-1225556 (+)
A/J ENSMUSG00195009487
 protein coding gene Chr8:1625106-1635361 (+)
A/J ENSMUSGG00195055392
 protein coding gene Chr8:1600552-1624122 (+)
AKR/J ENSMUSGG00220054672
 protein coding gene Chr8:1327091-1350678 (+)
AKR/J ENSMUSG00220010746
 protein coding gene Chr8:1351662-1361918 (+)
BALB/cJ ENSMUSGG00180054996
 protein coding gene Chr8:1252533-1276098 (+)
BALB/cJ ENSMUSG00180004468
 protein coding gene Chr8:1277082-1287336 (+)
C3H/HeJ ENSMUSG00175007543
 protein coding gene Chr8:1390161-1400416 (+)
C3H/HeJ ENSMUSGG00175054585
 protein coding gene Chr8:1365609-1389177 (+)
C57BL/6NJ ENSMUSGG00215055672
 protein coding gene Chr8:1279985-1303552 (+)
C57BL/6NJ ENSMUSG00215006318
 protein coding gene Chr8:1304536-1314785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030799
 protein coding gene Chr8:1140358-1175327 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210010300
 protein coding gene Chr8:1267679-1277936 (+)
CBA/J ENSMUSGG00210054770
 protein coding gene Chr8:1243128-1266695 (+)
DBA/2J ENSMUSG00185003906
 protein coding gene Chr8:1403735-1413990 (+)
DBA/2J ENSMUSGG00185057407
 protein coding gene Chr8:1379183-1402751 (+)
FVB/NJ ENSMUSG00205004489
 protein coding gene Chr8:1334223-1344478 (+)
FVB/NJ ENSMUSGG00205054582
 protein coding gene Chr8:1309665-1333239 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055708
 protein coding gene Chr8:3548741-3572300 (+)
LP/J ENSMUSG00230007699
 protein coding gene Chr8:3573284-3583538 (+)
NOD/ShiLtJ ENSMUSG00190011030
 protein coding gene Chr8:1377772-1388027 (+)
NOD/ShiLtJ ENSMUSGG00190054759
 protein coding gene Chr8:1353220-1376788 (+)
NZO/HlLtJ ENSMUSG00225015863
 protein coding gene Chr8:11437622-11447984 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010016335
 protein coding gene Chr8:1220905-1249588 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL25, C-C motif chemokine ligand 25
  • Synonyms
    Ckb15, Ck beta-15, SCYA25, TECK, TECKvar
  • Links
    NCBI Gene ID: 6370
    UniProt: O15444

  • Chr Location
    19p13.2; chr19:8052293-8062665 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    37
  • cDNA Data
    26
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023235 Ensembl Gene Model | MGI Sequence Detail 34811 C57BL/6J ±  kb
    transcript ENSMUST00000127460 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000120719 Ensembl | MGI Sequence Detail 228 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 26
      Primer pair 2
      Antibodies 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2142637
    References
    more
    • Summaries
      All 88
      Developmental Gene Expression 16
      Gene Ontology 8
      Phenotypes 20
    • Earliest
      J:42501 Vicari AP, et al., TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development. Immunity. 1997 Aug;7(2):291-301
    • Latest
      J:352089 Grammer C, et al., Vhl safeguards thymic epithelial cell identity and thymopoietic capacity by constraining Hif1a activity during development. iScience. 2024 Jul 19;27(7):110258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory