Cdk12 MGI Mouse Gene Detail - MGI:1098802 - cyclin dependent kinase 12

Symbol

Cdk12
Name

cyclin dependent kinase 12
Synonyms

1810022J16Rik, Crk7, Crkrs, D11Ertd752e

Feature Type

protein coding gene
IDs

MGI:1098802
NCBI Gene: 69131
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:98093885-98169330 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.75 cM, cytoband D
Mapping Data

6 experiments

SNPs within 2kb

1566 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098802	protein coding gene	Chr11:98093259-98171941 (+)
129S1/SvImJ	ENSMUSG00200050418	protein coding gene	Chr11:95342352-95391052 (+)
A/J	ENSMUSG00195051807	protein coding gene	Chr11:95063922-95112429 (+)
AKR/J	ENSMUSG00220049711	protein coding gene	Chr11:95323027-95371537 (+)
BALB/cJ	ENSMUSG00180046950	protein coding gene	Chr11:95335713-95384225 (+)
C3H/HeJ	ENSMUSG00175042661	protein coding gene	Chr11:95322417-95371116 (+)
C57BL/6NJ	ENSMUSG00215052935	protein coding gene	Chr11:94912003-94960511 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017077	protein coding gene	Chr11:93987374-94063783 (+)
CAST/EiJ	ENSTCUG00005048245	protein coding gene	Chr11:94775240-94823505 (+)
CBA/J	ENSMUSG00210052006	protein coding gene	Chr11:95025975-95074480 (+)
DBA/2J	ENSMUSG00185045760	protein coding gene	Chr11:95372299-95421003 (+)
FVB/NJ	ENSMUSG00205037423	protein coding gene	Chr11:95239219-95287922 (+)
JF1/MsJ	ENSUMUG00000035295	protein coding gene	Chr11:95677259-95726509 (+)
LP/J	ENSMUSG00230050679	protein coding gene	Chr11:96425231-96473931 (+)
NOD/ShiLtJ	ENSMUSG00190051392	protein coding gene	Chr11:95413721-95462420 (+)
NZO/HlLtJ	ENSMUSG00225050413	protein coding gene	Chr11:98477290-98525990 (+)
PWK/PhJ	ENSLUMG00010050268	protein coding gene	Chr11:95229488-95278618 (+)
SPRET/EiJ	ENSMSPG00010043224	protein coding gene	Chr11:95723061-95770970 (+)
WSB/EiJ	ENSIUOG00005043347	protein coding gene	Chr11:95178127-95227068 (+)

Human Ortholog

CDK12, cyclin dependent kinase 12

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDK12, cyclin dependent kinase 12
Synonyms

CRK7, CRKR, CRKRS
Links

HGNC:24224

NCBI Gene ID: 51755

UniProt: Q9NYV4
Chr Location

17q12; chr17:39461437-39567559 (+) GRCh38

MGI Vertebrate Homology

Cdk12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDK12
Gene Tree

Cdk12

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Phenotype Summary

22 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

6
Gene trapped

17
Targeted

6
Genomic Mutations

1 involving Cdk12
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

76 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality between implantation and E6.5 with decreased proliferation and increased apoptosis in the inner cell mass.

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All GO Annotations

55
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
Tissues

32
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDK12

Xenbase cdk12

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All Sequences

84
RefSeq

27
UniProt

3
CCDS

CCDS25342.1, CCDS48901.1, CCDS48902.1

Ensembl

ENSMUSG00000003119 (Evidence)
NCBI Gene

69131

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003119	Ensembl Gene Model \| MGI Sequence Detail	75446	C57BL/6J	± kb
transcript	ENSMUST00000107538	Ensembl \| MGI Sequence Detail	5143	Not Applicable
polypeptide	ENSMUSP00000103162	Ensembl \| MGI Sequence Detail	1484	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005884 cyclin-dependent kinase 12

(term hierarchy)
EC

2.7.11.1, 2.7.11.22, 2.7.11.23
InterPro Domains

IPR050108 Cyclin-dependent kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q14AX6 6 sites, 1 O-linked glycan (6 sites)

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All nucleic 24

cDNA 21

Primer pair 2

Other 1

Antibodies 1

Microarray probesets 10

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MGI:1289232, MGI:1916381, MGI:2144249

Summaries

All 68

Developmental Gene Expression 4

Gene Ontology 13

Phenotypes 26
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:387591 Yin Q, et al., Genetic landscape of morphine response in BXD recombinant inbred mice. HGG Adv. 2026 Jan 15;7(1):100535

TSS for Cdk12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104704	Chr11:98093564-98093575 (+)	-315 bp
Tssr104705	Chr11:98093584-98093627 (+)	-279 bp
Tssr104706	Chr11:98093641-98093646 (+)	-241 bp
Tssr104707	Chr11:98094133-98094174 (+)	269 bp
Tssr104708	Chr11:98101622-98101654 (+)	7,753 bp
Tssr104709	Chr11:98108032-98108038 (+)	14,150 bp
Tssr104710	Chr11:98139141-98139147 (+)	45,259 bp
Tssr104711	Chr11:98143899-98143904 (+)	50,017 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24