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Sepsecs Gene Detail
Summary
  • Symbol
    Sepsecs
  • Name
    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  • Synonyms
    D5Ertd135e, SecS, SLA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098791
    NCBI Gene: 211006
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52797429-52827050 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 28.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098791
 protein coding gene Chr5:52797429-52827104 (-)
129S1/SvImJ ENSMUSG00200001154
 protein coding gene Chr5:48350636-48380257 (-)
A/J ENSMUSG00195015154
 protein coding gene Chr5:47710269-47739900 (-)
AKR/J ENSMUSG00220000630
 protein coding gene Chr5:47779931-47809564 (-)
BALB/cJ ENSMUSG00180006178
 protein coding gene Chr5:47479570-47509386 (-)
C3H/HeJ ENSMUSG00175014883
 protein coding gene Chr5:49500134-49529767 (-)
C57BL/6NJ ENSMUSG00215001783
 protein coding gene Chr5:48272455-48302078 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027218
 protein coding gene Chr5:46594357-46623399 (-)
CAST/EiJ ENSTCUG00005003087
 protein coding gene Chr5:47632998-47662998 (-)
CBA/J ENSMUSG00210024102
 protein coding gene Chr5:48460521-48490154 (-)
DBA/2J ENSMUSG00185000065
 protein coding gene Chr5:50338987-50368620 (-)
FVB/NJ ENSMUSG00205002926
 protein coding gene Chr5:47289823-47319455 (-)
JF1/MsJ ENSUMUG00000000498
 protein coding gene Chr5:54918067-54947685 (-)
LP/J ENSMUSG00230009930
 protein coding gene Chr5:55014272-55043893 (-)
NOD/ShiLtJ ENSMUSG00190000499
 protein coding gene Chr5:47406026-47435659 (-)
NZO/HlLtJ ENSMUSG00225028187
 protein coding gene Chr5:60118676-60148309 (-)
PWK/PhJ ENSLUMG00010001440
 protein coding gene Chr5:47580825-47610501 (-)
SPRET/EiJ ENSMSPG00010012374
 protein coding gene Chr5:49063879-49093463 (-)
WSB/EiJ ENSIUOG00005018071
 protein coding gene Chr5:50378931-50408557 (-)



Homology
more
  • Human Ortholog
    SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  • Synonyms
    LP, PCH2D, SecS, SLA, SLA/LP, SLA-p35
  • Links
    NCBI Gene ID: 51091
    UniProt: Q9HD40

  • Chr Location
    4p15.2; chr4:25120014-25160582 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SEPSECS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a missense mutation exhibit perinatal lethality, low birth weight, cyanosis, cardio-respiratory failure, and absent milk spots. Mice homozygous for a knock-out allele show embryonic growth retardation, small egg cylinders, disorganized extraembryonic tissue, failure of primitive streak formation and gastrulation, and complete embryonic lethality by E9.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    103
  • cDNA Data
    13
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029173 Ensembl Gene Model | MGI Sequence Detail 29622 C57BL/6J ±  kb
    transcript ENSMUST00000031069 Ensembl | MGI Sequence Detail 5252 Not Applicable  
    polypeptide ENSMUSP00000031069 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140795
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 28
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory