Clk2 MGI Mouse Gene Detail - MGI:1098669

Symbol

Clk2
Name

CDC-like kinase 2

Feature Type

protein coding gene
IDs

MGI:1098669
NCBI Gene: 12748
Alliance

gene page

Sequence Map

Chr3:89072102-89084228 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 39.01 cM
Mapping Data

2 experiments

SNPs within 2kb

38 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098669	protein coding gene	Chr3:89072102-89084394 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027418	protein coding gene	Chr3:89362430-89374460 (+)
A/J	MGP_AJ_G0027382	protein coding gene	Chr3:86402767-86414907 (+)
AKR/J	MGP_AKRJ_G0027346	protein coding gene	Chr3:88498751-88512190 (+)
BALB/cJ	MGP_BALBcJ_G0027391	protein coding gene	Chr3:86372964-86385759 (+)
C3H/HeJ	MGP_C3HHeJ_G0027133	protein coding gene	Chr3:88698544-88711424 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027837	protein coding gene	Chr3:92743618-92757237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025189	protein coding gene	Chr3:81891264-81903369 (+)
CAST/EiJ	MGP_CASTEiJ_G0026579	protein coding gene	Chr3:89044868-89056982 (+)
CBA/J	MGP_CBAJ_G0027107	protein coding gene	Chr3:95920698-95936388 (+)
DBA/2J	MGP_DBA2J_G0027245	protein coding gene	Chr3:85789007-85801126 (+)
FVB/NJ	MGP_FVBNJ_G0027213	protein coding gene	Chr3:84128949-84140819 (+)
LP/J	MGP_LPJ_G0027354	protein coding gene	Chr3:90442972-90456436 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027233	protein coding gene	Chr3:102136878-102150566 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027896	protein coding gene	Chr3:88250876-88263498 (+)
PWK/PhJ	MGP_PWKPhJ_G0026313	protein coding gene	Chr3:85658212-85670435 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026132	protein coding gene	Chr3:87417879-87430035 (+)
WSB/EiJ	MGP_WSBEiJ_G0026661	protein coding gene	Chr3:88638668-88650554 (+)

Human Ortholog

CLK2, CDC like kinase 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLK2, CDC like kinase 2
Links

HGNC:2069

NCBI Gene ID: 1196

neXtProt AC: NX_P49760

UniProt: P49760
Chr Location

1q22; chr1:155262868-155278491 (-) GRCh38

MGI Vertebrate Homology

Clk2 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLK2
Gene Tree

Clk2

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Clk2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in the liver exhibit decreased hepatic fatty acid oxidation and ketogenesis.

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All GO Annotations

28
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

19
cDNA Data

67
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clk2

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All Sequences

63
RefSeq

4
UniProt

8
CCDS

CCDS17491.1, CCDS50958.1

Ensembl

ENSMUSG00000068917 (Evidence)
NCBI Gene

12748

			Length	Strain/Species	Flank
genomic	ENSMUSG00000068917	Ensembl Gene Model \| MGI Sequence Detail	12127	C57BL/6J	± kb
transcript	ENSMUST00000121931	Ensembl \| MGI Sequence Detail	2112	Not Applicable
polypeptide	ENSMUSP00000113861	Ensembl \| MGI Sequence Detail	500	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005585 dual specificity protein kinase CLK2

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 69

cDNA 68

Primer pair 1

Microarray probesets 3

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MGI:2139908

Summaries

All 49

Developmental Gene Expression 3

Diseases 1

Gene Ontology 11

Phenotypes 16
Earliest

J:43003 Nayler O, et al., Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Biochem J. 1997 Sep 15;326(Pt 3):693-700
Latest

J:339690 Norberto S, et al., CLK2 in GABAergic neurons is critical in regulating energy balance and anxiety-like behavior in a gender-specific fashion. Front Endocrinol (Lausanne). 2023;14:1172835

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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