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Bpgm Gene Detail
Summary
  • Symbol
    Bpgm
  • Name
    2,3-bisphosphoglycerate mutase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098242
    NCBI Gene: 12183
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34453291-34482071 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.01 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098242
 protein coding gene Chr6:34453142-34482548 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030560
 protein coding gene Chr6:32558786-32590406 (+)
A/J MGP_AJ_G0030533
 protein coding gene Chr6:31167535-31194384 (+)
AKR/J MGP_AKRJ_G0030460
 protein coding gene Chr6:32225638-32255285 (+)
BALB/cJ MGP_BALBcJ_G0030543
 protein coding gene Chr6:31347730-31375414 (+)
C3H/HeJ MGP_C3HHeJ_G0030256
 protein coding gene Chr6:32173718-32201155 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030997
 protein coding gene Chr6:33386779-33416583 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028209
 protein coding gene Chr6:29262028-29291953 (+)
CAST/EiJ MGP_CASTEiJ_G0029658
 protein coding gene Chr6:31995070-32025438 (+)
CBA/J MGP_CBAJ_G0030234
 protein coding gene Chr6:34659522-34691211 (+)
DBA/2J MGP_DBA2J_G0030378
 protein coding gene Chr6:31039711-31068288 (+)
FVB/NJ MGP_FVBNJ_G0030332
 protein coding gene Chr6:30840755-30869539 (+)
LP/J MGP_LPJ_G0030465
 protein coding gene Chr6:32682655-32712907 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030368
 protein coding gene Chr6:37001544-37030089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031027
 protein coding gene Chr6:32097834-32127267 (+)
PWK/PhJ MGP_PWKPhJ_G0029372
 protein coding gene Chr6:30654851-30684672 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029208
 protein coding gene Chr6:31757471-31789831 (+)
WSB/EiJ MGP_WSBEiJ_G0029734
 protein coding gene Chr6:32018935-32048382 (+)



Homology
more
  • Human Ortholog
    BPGM, bisphosphoglycerate mutase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BPGM, bisphosphoglycerate mutase
  • Synonyms
    DPGM, ECYT8
  • Links
    NCBI Gene ID: 669
    neXtProt AC: NX_P07738
    UniProt: P07738

  • Chr Location
    7q33; chr7:134646811-134679816 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BPGM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for an ENU-induced point mutation has protective effect against cerebral malaria and severe malarial anemia owing to increased erythropoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    101
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12183 NCBI Gene Model | MGI Sequence Detail 28781 C57BL/6J ±  kb
    transcript NM_007563 RefSeq | MGI Sequence Detail 1594 C57BL/6  
    polypeptide P15327 UniProt | EBI | MGI Sequence Detail 259 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141391, MGI:2141531, MGI:2141777
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 8
    • Earliest
      J:43382 Le Boulch P, et al., Molecular cloning and nucleotide sequence of murine 2,3-bisphosphoglycerate mutase cDNA. Biochem Biophys Res Commun. 1988 Oct 31;156(2):874-81
    • Latest
      J:301620 Xu G, et al., Bisphosphoglycerate Mutase Deficiency Protects against Cerebral Malaria and Severe Malaria-Induced Anemia. Cell Rep. 2020 Sep 22;32(12):108170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory