Impact MGI Mouse Gene Detail - MGI:1098233 - impact, RWD domain protein

Symbol

Impact
Name

impact, RWD domain protein
Synonyms

E430016J11Rik

Feature Type

protein coding gene
IDs

MGI:1098233
NCBI Gene: 16210
Alliance

genome feature page
Transcription Start Sites

6 TSS

Sequence Map

Chr18:13088909-13126007 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 6.87 cM, cytoband A2-B2
Mapping Data

2 experiments

SNPs within 2kb

1190 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098233	protein coding gene	Chr18:13087747-13126007 (+)
129S1/SvImJ	ENSMUSG00200019223	protein coding gene	Chr18:10027242-10064567 (+)
A/J	ENSMUSG00195002259	protein coding gene	Chr18:10217978-10255078 (+)
AKR/J	ENSMUSG00220011601	protein coding gene	Chr18:10212472-10249577 (+)
BALB/cJ	ENSMUSG00180003928	protein coding gene	Chr18:10667027-10704132 (+)
C3H/HeJ	ENSMUSG00175004394	protein coding gene	Chr18:10206329-10243435 (+)
C57BL/6NJ	ENSMUSG00215014108	protein coding gene	Chr18:9928440-9965544 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022010	protein coding gene	Chr18:9549116-9570290 (+)
CAST/EiJ	ENSTCUG00005016779	protein coding gene	Chr18:10003706-10040823 (+)
CBA/J	ENSMUSG00210020086	protein coding gene	Chr18:10215152-10252253 (+)
DBA/2J	ENSMUSG00185007753	protein coding gene	Chr18:10223386-10260483 (+)
FVB/NJ	ENSMUSG00205018761	protein coding gene	Chr18:9987679-10024780 (+)
JF1/MsJ	ENSUMUG00000021771	protein coding gene	Chr18:10267596-10304929 (+)
LP/J	ENSMUSG00230011838	protein coding gene	Chr18:12283959-12308961 (+)
NOD/ShiLtJ	ENSMUSG00190009285	protein coding gene	Chr18:9987847-10024948 (+)
NZO/HlLtJ	ENSMUSG00225027691	protein coding gene	Chr18:12205178-12242274 (+)
PWK/PhJ	ENSLUMG00010015513	protein coding gene	Chr18:10478555-10515768 (+)
SPRET/EiJ	ENSMSPG00010004781	protein coding gene	Chr18:10161373-10198942 (+)
WSB/EiJ	ENSIUOG00005019289	protein coding gene	Chr18:10106191-10143272 (+)

Human Ortholog

IMPACT, impact RWD domain protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IMPACT, impact RWD domain protein
Synonyms

RWDD5
Links

HGNC:20387

NCBI Gene ID: 55364

UniProt: Q9P2X3
Chr Location

18q11.2; chr18:24426634-24453531 (+) GRCh38

MGI Vertebrate Homology

Impact stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IMPACT
Gene Tree

Impact

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Phenotype Summary

23 phenotypes from 3 alleles in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

9
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display resistance to high fat diet induced obesity and reduced body temperature and glucose levels after fasting.

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All GO Annotations

20
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

645
Tissues

43
cDNA Data

96
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase impact

ZFIN impact

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All Sequences

62
RefSeq

8
UniProt

6
CCDS

CCDS29068.1

Ensembl

ENSMUSG00000024423 (Evidence)
NCBI Gene

16210

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024423	Ensembl Gene Model \| MGI Sequence Detail	37099	C57BL/6J	± kb
transcript	ENSMUST00000025290	Ensembl \| MGI Sequence Detail	3763	Not Applicable
polypeptide	ENSMUSP00000025290	Ensembl \| MGI Sequence Detail	318	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009019 protein IMPACT

(term hierarchy)
InterPro Domains

IPR023582 Impact family

IPR001498 Impact, N-terminal

IPR036956 Impact, N-terminal domain superfamily

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR006575 RWD domain

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

IPR020569 Uncharacterised protein family UPF0029, Impact, conserved site
GlyGen

O55091 1 site, 1 O-linked glycan (1 site)

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All nucleic 99

cDNA 96

Primer pair 3

Microarray probesets 5

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MGI:2442038

Summaries

All 54

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 12
Earliest

J:42447 Hagiwara Y, et al., Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9249-54
Latest

J:302583 Jiang W, et al., ZFP57 dictates allelic expression switch of target imprinted genes. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2005377118

TSS for Impact:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr150119	Chr18:13088864-13088876 (+)	-39 bp
Tssr150120	Chr18:13088878-13088908 (+)	-16 bp
Tssr150121	Chr18:13105282-13105371 (+)	16,418 bp
Tssr150122	Chr18:13107475-13107494 (+)	18,576 bp
Tssr150123	Chr18:13107560-13107643 (+)	18,693 bp
Tssr150124	Chr18:13124583-13124588 (+)	35,677 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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