Kif17 MGI Mouse Gene Detail - MGI:1098229

Symbol

Kif17
Name

kinesin family member 17
Synonyms

5930435E01Rik, Kif17b, N-4 kinesin

Feature Type

protein coding gene
IDs

MGI:1098229
NCBI Gene: 16559
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:137989562-138029284 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.07 cM, cytoband D3
Mapping Data

3 experiments

SNPs within 2kb

515 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098229	protein coding gene	Chr4:137977746-138029284 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028992	protein coding gene	Chr4:140969707-141028943 (+)
A/J	MGP_AJ_G0028951	protein coding gene	Chr4:134949548-135002902 (+)
AKR/J	MGP_AKRJ_G0028903	protein coding gene	Chr4:138798829-138852165 (+)
BALB/cJ	MGP_BALBcJ_G0028975	protein coding gene	Chr4:135621355-135674851 (+)
C3H/HeJ	MGP_C3HHeJ_G0028689	protein coding gene	Chr4:139159227-139214061 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029416	protein coding gene	Chr4:145974291-146039980 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026687	protein coding gene	Chr4:127932623-127983917 (+)
CAST/EiJ	MGP_CASTEiJ_G0028121	protein coding gene	Chr4:137325628-137368060 (+)
CBA/J	MGP_CBAJ_G0028654	protein coding gene	Chr4:150129858-150198224 (+)
DBA/2J	MGP_DBA2J_G0028803	protein coding gene	Chr4:135326507-135380280 (+)
FVB/NJ	MGP_FVBNJ_G0028770	protein coding gene	Chr4:134348077-134400058 (+)
LP/J	MGP_LPJ_G0028902	protein coding gene	Chr4:141053518-141106005 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028796	protein coding gene	Chr4:154149671-154214700 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029454	protein coding gene	Chr4:139310232-139364675 (+)
PWK/PhJ	MGP_PWKPhJ_G0027841	protein coding gene	Chr4:132185927-132229995 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027667	protein coding gene	Chr4:135087884-135140516 (+)
WSB/EiJ	MGP_WSBEiJ_G0028199	protein coding gene	Chr4:139541432-139595800 (+)

Human Ortholog

KIF17, kinesin family member 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF17, kinesin family member 17
Synonyms

KIF17B, KIF3X, KLP-2, OSM-3
Links

HGNC:19167

NCBI Gene ID: 57576

neXtProt AC: NX_Q9P2E2

UniProt: Q9P2E2
Chr Location

1p36.12; chr1:20661630-20718017 (-) GRCh38

MGI Vertebrate Homology

Kif17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIF17
Gene Tree

Kif17

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

7
Genomic Mutations

3 involving Kif17
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a knock-out allele exhibit impaired anterograde neuron transport, reduced NMDA-mediated synaptic currents, impaired synaptic plasticity, impaired long term object recognition memory, impaired spatial learning, and impaired contextual conditioning.

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All GO Annotations

40
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

52
cDNA Data

10
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kif17

ZFIN kif17

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All Sequences

44
RefSeq

4
UniProt

5
CCDS

CCDS18823.1, CCDS57307.1

Ensembl

ENSMUSG00000028758 (Evidence)
NCBI Gene

16559

			Length	Strain/Species	Flank
genomic	16559	NCBI Gene Model \| MGI Sequence Detail	39723	C57BL/6J	± kb
transcript	NM_010623	RefSeq \| MGI Sequence Detail	3915	C57BL/6
polypeptide	Q99PW8	UniProt \| EBI \| MGI Sequence Detail	1038	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009291 kinesin-like protein KIF17

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 12

Genomic 2

cDNA 10

Microarray probesets 4

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MGI:2140576, MGI:2444040

Summaries

All 57

Developmental Gene Expression 5

Gene Ontology 15

Phenotypes 11
Earliest

J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
Latest

J:267509 Lewis TR, et al., Kif17 phosphorylation regulates photoreceptor outer segment turnover. BMC Cell Biol. 2018 Nov 20;19(1):25

TSS for Kif17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39846	Chr4:137989500-137989569 (+)	-27 bp
Tssr1351	Chr4:137989790-137989815 (+)	241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23