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Ackr1 Gene Detail
Summary
  • Symbol
    Ackr1
  • Name
    atypical chemokine receptor 1 (Duffy blood group)
  • Synonyms
    CCBP1, CD234, Darc, Dfy, ESTM35, FY
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097689
    NCBI Gene: 13349
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:173159453-173161070 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1097689
 protein coding gene Chr1:173159453-173161317 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016807
 protein coding gene Chr1:179262398-179264264 (-)
A/J MGP_AJ_G0016784
 protein coding gene Chr1:171913007-171914873 (-)
AKR/J MGP_AKRJ_G0016750
 protein coding gene Chr1:177138016-177139882 (-)
BALB/cJ MGP_BALBcJ_G0016744
 protein coding gene Chr1:172455563-172457429 (-)
C3H/HeJ MGP_C3HHeJ_G0016569
 protein coding gene Chr1:177667412-177669278 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017207
 protein coding gene Chr1:185235444-185237308 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014913
 protein coding gene Chr1:163540806-163542673 (-)
CAST/EiJ MGP_CASTEiJ_G0016149
 protein coding gene Chr1:177062535-177064399 (-)
CBA/J MGP_CBAJ_G0016543
 protein coding gene Chr1:191844687-191846553 (-)
DBA/2J MGP_DBA2J_G0016650
 protein coding gene Chr1:170874083-170875949 (-)
FVB/NJ MGP_FVBNJ_G0016647
 protein coding gene Chr1:169085158-169087024 (-)
LP/J MGP_LPJ_G0016721
 protein coding gene Chr1:180336253-180338119 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016673
 protein coding gene Chr1:199060313-199062179 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017243
 protein coding gene Chr1:177030956-177032822 (-)
PWK/PhJ MGP_PWKPhJ_G0015936
 protein coding gene Chr1:170235534-170237400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015718
 protein coding gene Chr1:175961123-175962993 (-)
WSB/EiJ MGP_WSBEiJ_G0016213
 protein coding gene Chr1:177127846-177129712 (-)



Homology
more
  • Human Ortholog
    ACKR1, atypical chemokine receptor 1 (Duffy blood group)
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACKR1, atypical chemokine receptor 1 (Duffy blood group)
  • Synonyms
    CCBP1, CD234, DARC, DARC/ACKR1, Dfy, FY, GPD, GpFy, WBCQ1
  • Links
    NCBI Gene ID: 2532
    neXtProt AC: NX_Q16570
    UniProt: Q16570

  • Chr Location
    1q23.2; chr1:159204013-159206500 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human ACKR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants are healthy, but erythrocytes lack CXC and CC chemokine-binding activity, such that when challenged with LPS result in increased inflammatory infiltrates in lung and liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    109
  • cDNA Data
    23
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13349 NCBI Gene Model | MGI Sequence Detail 1618 C57BL/6J ±  kb
    transcript NM_010045 RefSeq | MGI Sequence Detail 1163 C57BL/6  
    polypeptide Q9QUI6 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 21
      cDNA 24
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1334436
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 36
    • Earliest
      J:38315 Luo H, et al., Cloning, characterization, and mapping of a murine promiscuous chemokine receptor gene: homolog of the human Duffy gene [letter]. Genome Res. 1997 Sep;7(9):932-41
    • Latest
      J:320498 Dei Zotti F, et al., A New Murine Model of Primary Autoimmune Hemolytic Anemia (AIHA). Front Immunol. 2021;12:752330
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    03/14/2023
    MGI 6.22     		The Jackson Laboratory